4种钆类造影剂中钆含量的热重分析测定  

Determination of Gadolinium in Four Gadolinium Contrast Agents by Thermogravimetric Analysis

作　　者：谭继华 赵婷婷 潘红娟 TAN Jihua;ZHAO Tingting;PAN Hongjuan(China State Institute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]中国医药工业研究总院,上海201203

出　　处：《中国医药工业杂志》2020年第4期520-523,共4页Chinese Journal of Pharmaceuticals

摘　　要：本试验采用热重分析法测定钆布醇一水合物、钆贝葡胺、钆双胺、钆喷酸单葡胺4种钆类造影剂中钆的含量。通过单因素试验对气氛氛围和称样质量等进行优化。结果显示,本法检测条件为气氛氛围(O2)60 ml/min,从室温以20℃/min升至800℃。精密度试验中,经优化后的热重分析法测定钆含量的相对误差及RSD均在2%以内,可为后续测定钆含量的研究提供参考。A thermogravimetric analysis method was developed for the determination of gadolinium in four gadolinium contrast agents namely gadobutrol monohydrate,gadobenate dimeglumine,gadodiamide and gadolinium monoglumide.The process parameters of the thermogravimetric analysis like sample gas atomosphere and sample weight were optimized through single factor test.The optimal conditions were as follows:the flow rate of sample gas atomosphere(O2)was 60 ml/min,and temperature was increased from room temperature to 800℃at the heating rate of 20℃/min.The results of precision test showed that the relative error and RSD of the gadolinium content determined by the optimized thermogravimetric analysis were within 2%.This paper provided a reference for the subsequent research on the determination of gadolinium content.

关 键 词：热重分析 钆类造影剂 钆含量 钆布醇一水合物 钆贝葡胺 钆双胺 钆喷酸单葡胺 

分 类 号：O657.99[理学—分析化学] TQ421.7[理学—化学]