1例肾病综合征患儿个体化应用环孢素的病例分析  

Case analysis of individualized application of cyclosporine in a child patient with nephrotic syndrome

作　　者：洪钰 陈超阳[1] 刘阳[3] 周颖[1] 崔一民[1] HONG Yu;CHEN Chao-yang;LIU Yang;ZHOU Ying;CUI Yi-min(Department of Pharmacy,Peking University First Hospital,Beijing 100034,China;Department of Pharmacy,The Second Hospital of Anhui Medical University,Hefei 230601,Anhui Province,China;Department of Pharmacy,Dalian Children*s Hospital of Dalian Medical University,Dalian 116012,Liaoning Province,China)

机构地区：[1]北京大学第一医院药学部,北京100034 [2]安徽医科大学第二附属医院药学部,安徽合肥230601 [3]大连市儿童医院药剂科,辽宁大连116012

出　　处：《中国临床药理学杂志》2020年第7期849-850,856,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的探讨药物相互作用在临床药物治疗中的积极作用。方法临床药师参与1例肾病综合征患儿应用环孢素的治疗过程,通过检索大量文献资料,积极应用药物相互作用,提高了药物治疗效果,结合治疗药物监测(TDM),保障患儿用药安全。结果与结论积极的药物相互作用为临床药学研究工作开辟了新的方向,也对临床药物治疗工作提供了新的循证证据。临床药师应积极参与临床工作,从药学角度解决临床问题,提高药物治疗效果,降低药物不良反应的发生。Objective To explore the positive effects of drug interactions in clinical drug therapy.Methods The clinical pharmacist participated in the treatment of a child patient with nephrotic syndrome using cyclosporine.By searching a large number of literature and actively applying drug interactions, the drug treatment effect was improved, and the combination of therapeutic drug monitoring(TDM) was used to ensure the safety of medication for children.Results and Conclusion Positive drug interactions have opened up new directions for clinical pharmacy research and provided new evidence-based evidence for clinical drug treatment.Clinical pharmacists should actively participate in clinical work, solve clinical problems from the perspective of pharmacy, improve the effect of drug treatment, and reduce the occurrence of adverse drug reactions.

关 键 词：地尔硫[艹卓] 环孢素 药物相互作用 肾病综合征 细胞色素P4503A 

分 类 号：R97[医药卫生—药品]