武汉汉族人群阿司匹林抵抗易感基因血管内皮聚集受体-1 rs12041331位点多态性分析  

Research on the aspirin resistance susceptibility gene platelet endothelial aggregation receptor 1 rs12041331 polymorphism among the Hans in Wuhan

作　　者：马良鹏 梅明 刘剑敏[1] 蒋捷[1] 胡磊[1] 徐宏峰[1] 黄鹤归 MA Liang-peng;MEI Ming;LIU Jian-min;JIANG Jie;HU Lei;XU Hong-feng;HUANG He-gui(Department of Pharmacy,Wuhan NO.1 Hospital,Wuhan 430022,Hubei Province,China)

机构地区：[1]武汉市第一医院药学部,湖北武汉430022

出　　处：《中国临床药理学杂志》2020年第8期947-949,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81803646);湖北省自然科学基金资助项目(2018CFB326);武汉市卫计委指导基金资助项目(WX18Z33)。

摘　　要：目的研究武汉汉族人群阿司匹林抵抗(AR)易感基因血管内皮聚集受体-1(PEAR1)rs12041331位点多态性分布特征。方法回顾性分析武汉市第一医院849例汉族人群PEAR1 rs12041331位点基因分型检测结果。结果PEAR1 rs12041331位点G、A等位基因频率分别为59.31%和40.69%,共检出3种基因型:GG、GA及AA,频率分别为35.92%、46.76%及17.31%。男性A等位基因及AA基因型频率显著高于女性(P<0.05,P<0.05)。武汉人A等位基因及AA基因型频率显著低于大连、广州(P<0.05,P<0.01),高于新乡(P<0.01)。武汉人AA基因型频率高于美国白人(P<0.05),低于美国黑人(P<0.01)。结论AR易感基因PEAR1 rs12041331位点多态性分布具有性别、地区、种族差异。Objective To identity the genotype distribution of aspirin resistance susceptibility gene platelet endothelial aggregation receptor 1(PEAR1)among Hans in Wuhan.Methods A retrospective study of PEAR1 variant rs12041331 genetic testings was conducted in Han population from Wuhan NO.1 Hospital.Results Allele frequencies of G and A were 59.31%and 40.69%,respectively.Three genotypes were identified,including GG,GA,and AA.Genotype frequencies were 35.92%,46.76%,17.31%,respectively.Allele frequencies of A and genotype frequencies of AA in male were higher than that in female(P<0.05,P<0.05).Allele frequencies of A and genotype frequencies of AA in Wuhan were lower than that in Dalian,Guangzhou(P<0.05,P<0.01).Genotype frequencies of AA in Wuhan people were higher than that in European American(P<0.05),and lower than that in African American(P<0.01).Conclusion The polymorphism of the PEAR1 variant rs12041331 exhibits gender,regional and racial difference.

关 键 词：阿司匹林抵抗 血管内皮聚集受体-1 性别 地区 种族 基因多态性 

分 类 号：R97[医药卫生—药品]