γ-氨基丁酸能信号系统与胰岛素抵抗  

Relationship betweenγ-aminobutyric acid signaling system and insulin resistance

作　　者：陈琦[1] 袁莉[1] Chen Qi;Yuan Li(Department of Endocrinology,Union Hospital,The Affiliated Hospital of Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院内分泌科,武汉430022

出　　处：《国际内分泌代谢杂志》2020年第2期113-116,共4页International Journal of Endocrinology and Metabolism

摘　　要：γ-氨基丁酸(GABA)是一种重要的抑制性神经递质,研究发现,除了神经系统外,GABA还广泛分布于脂肪、肝脏、肌肉等对胰岛素敏感的组织。GABA可通过对糖脂代谢、炎性反应、免疫应答、肠道菌群等途径的调控,增强外周组织胰岛素信号转导,从而改善胰岛素抵抗,为2型糖尿病的防治提供了新的方向。γ-aminobutyric acid(GABA)is an important inhibitory neurotransmitter.Studies have found that GABA is widely distributed in fat,liver,muscle and other tissue sensitivity to insulin,in addition to the nervous system.GABA can enhance insulin signal transduction of peripheral tissue,improve insulin resistance through regulating glucolipid metabolism,immune response,inflammation and gut microbiota,it provides a new direction for the prevention and treatment of type 2 diabetes mellitus.

关 键 词：Γ-氨基丁酸 胰岛素抵抗 肥胖症 糖尿病 

分 类 号：R587[医药卫生—内分泌]