嘉兴市妊娠晚期孕妇B群链球菌的定植和围生结局分析  

Colonization of group B streptococcus in late-pregnant women and its relation with perinatal outcomes

作　　者：徐萍[1] 冯英[1] 杨柏财 叶金艳 XU Ping;FENG Ying;YANG Baicai(Department of Obstetrics,Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314000,China)

机构地区：[1]嘉兴市妇幼保健院产科,314000

出　　处：《浙江医学》2020年第8期851-853,共3页Zhejiang Medical Journal

基　　金：嘉兴市科技计划项目(2016AY23062)。

摘　　要：目的探讨嘉兴市妊娠晚期孕妇B群链球菌(GBS)定植情况、围生结局及药敏情况。方法选取2016年1月1日至2017年12月31日在本院产科进行定期产前检查及住院分娩的11 774例围生期孕妇为研究对象,以无菌拭子采集阴道下1/3的分泌物和直肠拭子并立即送检,将培养结果为阳性的650例孕妇作为GBS阳性组,阴性的11 124例孕妇随机抽取650例作为GBS阴性组。结果嘉兴市妊娠晚期孕妇GBS定植率为5.52%。GBS阳性组孕妇早产、胎膜早破和产褥感染发生率均高于GBS阴性组,差异均有统计学意义(均P<0.05)。650株GBS中未发现对青霉素G钠、氨苄西林、头孢他啶、头孢噻肟、利奈唑胺、美罗培南和万古霉素的耐药菌株;对红霉素和克林霉素的耐药率偏高,分别为80.62%和61.84%;对左氧氟沙星的耐药率为38.46%。结论妊娠晚期孕妇GBS定植可导致不良围生结局,预防性使用抗生素能有效减少不良围生结局的发生。Objective To investigate the colonization of group B streptococcus(GBS) in late-pregnant women and its relation with the perinatal outcomes. Methods Total 11 774 late-pregnant women, who underwent regular prenatal examination and hospital delivery from January 2016 to December 2017 in Jiaxing Maternity and Child Health Care Hospital, were chosen as the research objects. The secretion samples at lower third of the vagina and the rectal were taken with sterile swabs. 650 pregnant women with positive GBS culture were selected as GBS positive group, and 650 pregnant women with negative culture were randomly selected as GBS negative group. Results The colonization rate of GBS in late-pregnant women was 5.52%. The incidences of premature delivery, premature rupture of membranes and puerperal infection in GBS positive group were significantly higher than those in the GBS negative group(all P<0.05). In the 650 GBS isolates, there were no resistant strains to penicillin G,ampicillin, ceftazidime, cefotaxime, linezolid, meropenem or vancomycin;while the resistance rate to erythromycin, clindamycin and levofloxacin were 80.62%, 61.84% and 38.46%, respectively. Conclusion GBS colonization in late-pregnant women can lead to adverse perinatal outcomes, and this may be avoided by prophylactic administration of antibiotics.

关 键 词：B群链球菌 定植 妊娠 

分 类 号：R714.2[医药卫生—妇产科学]