热淋清颗粒辅助治疗急性肾盂肾炎膀胱湿热证  

Adjunctive Treatment of Reilinqing Granules on Acute Pyelonephritis and Bladder with Syndrome of Bladder Damp-Heat

作　　者：张志亮[1] 刘云[1] 邓智建[1] ZHANG Zhiliang;LIU Yun;DENG Zhijian(The First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,Henan Province,China)

机构地区：[1]新乡医学院第一附属医院,河南新乡453100

出　　处：《吉林中医药》2020年第4期490-493,共4页Jilin Journal of Chinese Medicine

基　　金：河南省医学科技攻关计划项目(201604167)。

摘　　要：目的探讨热淋清颗粒辅助治疗对急性肾盂肾炎膀胱湿热证的疗效以及对血清白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平的影响。方法选取2017年8月-2019年8月在新乡医学院第一附属医院就诊的急性肾盂肾炎患者108例,按随机数值表法分为观察组和对照组,各54例。对照组给予头孢氨苄片,口服,1次250~500 mg,每日4次;诺氟沙星胶囊,口服,1次400 mg,每日2次;碳酸氢钠片,口服,1次1~2片,每日3次。观察组在对照组治疗基础上接受热淋清颗粒,1次2袋,开水冲服,每日3次。连续2周后,比较2组症状消失时间、膀胱湿热证证症状评分、临床疗效;酶联免疫吸附法测定2组血清IL-6和TNF-α水平。结果观察组患者的发热(3.05±0.44)d、腰痛(10.05±1.75)d以及尿路刺激征(5.40±0.72)d的消失时间均显著短于对照组[(3.93±0.52)d,(12.17±1.94)d,(7.83±0.97)d](P<0.01);治疗后观察组膀胱湿热证症状评分明显低于对照组的81.48%(P<0.01);观察组总有效率为96.30%,显著高于对照组的81.48%(P<0.05);观察组治疗后血清IL-6(41.36±6.03)pg/mL和TNF-α(90.34±10.71)pg/mL水平明显低于对照组[(50.77±6.49)pg/mL和(109.44±12.78)pg/mL](P<0.01)。结论热淋清颗粒辅助治疗对急性肾盂肾炎膀胱湿热证的疗效明显,抑制血清IL-6和TNF-α水平可能是其治疗机制之一。Objective To investigate the efficacy of adjunctive treatment of Reilinqing granules on acute pyelonephritis with syndrome of bladder damp-heat and its effect on serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α.Methods One hundred and eight acute pyelonephritis patients admitted to the First Affiliated Hospital of Xinxiang Medical University from august of 2017 to august of 2019 were selected and were divided into the observation group and the control group (54 cases for each group).according to the random numerical table.The control group orally received Cephalexin tablets (250 to 500 mg/time,4 times/d),Norfloxacin capsule (400 mg/time and 2 times/d),and Bicarbonate sodium tablets (1-2 tablets/time and 3 times/d).On the basis of treatment of the control group,the observation group received boiled water a blunt of Reilinqing granules (2 bags/time and 3 times/d).After 2 weeks’ treatment,the disappearance time of symptom,symptoms scores of syndrome of bladder damp-heat,the clinical efficacy.The enzyme-linked immunosorbent assay was used to detect serum levels of IL-6 and TNF-αwere compared between the two groups.Results The disappearance time of fever (3.05±0.44) d,low back pain (10.05±1.75) d,and urinary tract irritation (5.40±0.72) d in the observation group was significantly shorter than the control group [(3.93±0.52) d,(12.17±1.94) d,(7.83±0.97)d](P<0.01).After treatment,the symptoms scores of syndrome of bladder damp-heat in the observation group were significantly lower than those in the control group (P<0.01).The total effective rate of the observation group was 96.30%,significantly higher than that of the control group (P<0.05).After treatment,serum levels of IL-6 (41.36±6.03) pg/mL and TNF-α (90.34±10.71) pg/mL in the observation group were signifi cantly lower th an those in the control group [(50.77±6.49) pg/mL and (109.44±12.78) p g/mL](P<0.01).Conclusion The efficacy of adjunctive treatment of Reilinqing granules on acute pyelonephritis and bladder with syndrome of bl

关 键 词：急性肾盂肾炎 热淋清颗粒 膀胱湿热证 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R969.4[医药卫生—药理学]