慢性乙型肝炎免疫机制的研究  

Study on the Immune Mechanism of Chronic Hepatitis B

作　　者：党便利 康文臻[1] 孙永涛[1] DANG Bian-li;KANG Wen-zhen;SUN Yong-tao(Military Infectious Diseases Diagnosis and Treatment Center,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,Shaanxi,China)

机构地区：[1]第四军医大学唐都医院全军感染病诊疗中心,陕西西安710038

出　　处：《医学信息》2020年第9期29-31,共3页Journal of Medical Information

基　　金：“十三五”科技重大专项(编号:2017ZX10202203-008-003,2017ZX10202101-003-007、2017ZX10202101-004-005、2017ZX10202102-001-011);陕西省重点研发计划(编号:S2018-YF-YBSF-0852)。

摘　　要：慢性乙型肝炎是一种影响全球公共卫生的传染病,由于乙型肝炎病毒(HBV)持续感染导致的常见慢性肝脏疾病。免疫应答水平决定了HBV是否继续感染,其中固有免疫仅能控制HBV的初期感染,而适应性免疫有助于清除感染病毒的细胞并提供长期免疫性保护。因此,机体免疫应答在慢性乙型肝炎的病毒清除、肝脏炎症损伤、疾病进展及治疗中发挥重要作用。本文将慢性乙型肝炎病毒感染的固有免疫和适应性免疫机制作一综述,以期为临床治疗提供参考。Chronic hepatitis B is an infectious disease that affects global public health.It is a common chronic liver disease caused by continuous infection of hepatitis B virus(HBV).The level of immune response determines whether HBV continues to be infected.Among them,innate immunity can only control the initial infection of HBV,and adaptive immunity helps to remove cells infected with the virus and provide long-term immune protection.Therefore,the body’s immune response plays an important role in the viral clearance of chronic hepatitis B,liver inflammation damage,disease progression and treatment.This article reviews the innate and adaptive immune mechanisms of chronic hepatitis B virus infection in order to provide a reference for clinical treatment.

关 键 词：慢性乙型肝炎 固有免疫 适应性免疫 

分 类 号：R512.62[医药卫生—内科学]