拜阿斯匹林、那曲肝素联合氯吡格雷治疗急性ST段抬高型心肌梗死疗效  

The Efficacy of Bayaspirin,Naltreparin Combined with Clopidogrel in the Treatment of Acute ST-segment Elevation Myocardial Infarction

作　　者：栾学冰 LUAN Xue-bing(Department of Cardiology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)

机构地区：[1]佳木斯市中心医院心血管内科,黑龙江佳木斯154002

出　　处：《医学信息》2020年第9期136-137,共2页Journal of Medical Information

摘　　要：目的观察拜阿斯匹林、那曲肝素联合氯吡格雷治疗急性ST段抬高型心肌梗死临床效果。方法选取2018年4月~2019年4月在我院诊治的102例急性ST段抬高型心肌梗死患者为研究对象,采用随机数字表法分为对照组和观察组,各51例。对照组采用拜阿斯匹林与那曲肝素联合治疗,观察组在对照组基础上加用氯吡格雷治疗,比较两组临床治疗总有效率、自发性ST段回落率、血管再通率及不良反应发生情况。结果观察组治疗总有效率为94.11%,高于对照组的80.39%,差异有统计学意义(P<0.05);观察组自发性ST段回落率为92.15%,高于对照组的76.47%,差异有统计学意义(P<0.05);观察组血管再通率为72.54%,高于对照组的54.90%,差异有统计学意义(P<0.05);观察组不良反应发生率为3.91%,与对照组的1.96%比较,差异无统计学意义(P>0.05)。结论拜阿斯匹林、那曲肝素联合氯吡格雷三联治疗急性ST段抬高型心肌梗死疗效确切,有助于提高自发性ST段回落率和血管再通率,且临床不良反应少,联合用药安全可靠。Objective To observe the clinical effect of bayaspirin,naltreparin combined with clopidogrel in the treatment of acute ST-segment elevation myocardial infarction.Methods A total of 102 patients with acute ST-segment elevation myocardial infarction diagnosed and treated in our hospital from April 2018 to April 2019 were selected as the research object. They were divided into a control group and an observation group with a random number table method, with 51 cases in each group.The control group was treated with bayaspirin and naltreparin, and the observation group was treated with clopidogrel on the basis of the control group. The total clinical treatment efficiency, spontaneous ST-segment fall rate, vascular recanalization rate, and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.11%, higher than 80.39% in the control group, the difference was statistically significant (P<0.05);the spontaneous ST segment fallback rate in the observation group was 92.15%, higher than the control group’s 76.47%, the difference was statistically significant (P <0.05);the vascular recanalization rate of the observation group was 72.54%, higher than that of the control group of 54.90%, the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was 3.91%, and compared with 1.96% of the control group, the difference was not statistically significant(P >0.05).Conclusion The combination of bayaspirin,naltreparin and clopidogrel in the treatment of acute ST-segment elevation myocardial infarction is definite, which is helpful to improve the spontaneous ST-segment fall rate and vascular recanalization rate,and there are few clinical adverse reactions, the combined medication is safe and reliable.

关 键 词：拜阿斯匹林 氯吡格雷 那曲肝素 ST段抬高型心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]