抗磷脂抗体对妊娠不良结局影响的研究进展  

Effects of antiphospholipid antibodies on adverse pregnancy outcomes

作　　者：史娇阳 彭小彧 陈晓[1] 孔祥 Shi Jiaoyang;Peng Xiaoyu;Chen Xiao;Kong Xiang(Department of Obstetrics and Gynecology,Dalian Medical University,Dalian 116044,China;Department of Obstetrics and Gynecology,Clinical Medical College,Yangzhou University,Yangzhou 225001,China)

机构地区：[1]大连医科大学妇产科,116044 [2]扬州大学临床医学院妇产科,225001

出　　处：《国际医药卫生导报》2020年第10期1357-1360,共4页International Medicine and Health Guidance News

基　　金：扬州市科技计划项目(YZ2017069)。

摘　　要：目前研究发现,抗磷脂抗体与妊娠不良结局相关;抗磷脂抗体对不良妊娠结局的影响机制可能是通过促进血栓形成、造成细胞免疫平衡紊乱、过度活化补体系统、损伤滋养细胞功能等导致病理妊娠,造成胎盘供血不足从而导致胎儿缺血缺氧,引起流产、胎儿窘迫、子痫前期、胎儿生长受限等并发症。在妊娠期间对孕产妇抗磷脂抗体进行筛查,及早对抗磷脂抗体阳性及抗磷脂综合征的孕产妇进行妊娠监测及临床干预,有助于预防及改善妊娠不良结局。At present,a large number of studies have confirmed the correlation between antiphospholipid antibodies and adverse pregnancy outcomes.The main mechanism of influence of antiphospholipid antibodies on adverse pregnancy outcomes is that it can promote the thrombosis,break the cell immune balance,over-activate the complement system,damage the trophoblast function,and lead to pathological pregnancy,resulting in fetal hypoxia caused by insufficient blood supply to the placenta and complications such as miscarriage,fetal distress,preeclampsia,and fetal growth restriction.Detecting maternal antiphospholipid antibodies during pregnancy on one hand and monitoring and clinically intervening the pregnant women with antiphospholipid syndrome who are positive in antiphospholipid antibodies as early as possible on the other hand are helpful in the prevention and improvement of adverse pregnancy outcomes.

关 键 词：抗磷脂抗体 抗心磷脂抗体 抗磷脂综合征 不良妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]