湖北荆州地区高危型HPV感染状况及流行病学特征研究  

The research on the infection status and epidemiological characteristics of high-risk HPV in Jingzhou area of Hubei Province

作　　者：訚璠 李滔[1] 唐全[1] 彭长华[1] 欧阳耀灵[1] 李承彬[1] 汤璇 YIN Fan;LI Tao;TANG Quan;PENG Changhua;OUYANG Yaoling;LI Chengbin;TANG Xuan(Department of Laboratory Medicine, Jingzhou Central Hospital, Jingzhou 434020, China)

机构地区：[1]湖北省荆州市中心医院检验医学部,湖北荆州434020

出　　处：《湖北大学学报（自然科学版）》2020年第3期311-315,共5页Journal of Hubei University：Natural Science

基　　金：荆州市中心医院青年科研创新团队(QNTD201901)资助。

摘　　要：为了解湖北荆州地区女性HRHPV感染的流行病学特征,采用荧光PCR方法检测就诊女性15种HRHPV基因型,用SPSS 23.0软件进行统计分析.结果表明,3677例就诊女性总感染率为20.64%(759例),优势型别依次为HPV52(6.53%,240例)、HPV58(3.51%,129例)、HPV16(2.99%,110例)、HPV39(2.64%,97例)与HPV68(2.04%,75例).HRHPV感染率最低年龄段为30~39岁(18.10%,187例),最高年龄段为60~69岁(37.61%,41例).HRHPV感染模式中单一型别感染率为14.11%(519例),双重感染率为4.81%(177例),三重、四重与五重感染均有检出.HRHPV的感染率(P<0.01)和感染模式(P<0.05)在不同年龄段间有统计学差异.荆州地区女性HRHPV感染型别以HPV52、HPV58和HPV16型为主.感染模式以单一型别感染为主,双重感染次之.年龄与HRHPV的阳性率和多重感染率正相关.To investigate the epidemiological characteristics of the infection of female HRHPV in Jingzhou,fifteen HRHPV genotypes were detected by fluorescent PCR and statistical analysis was performed with SPSS 23.0 software.The total infection rate of 3677 women was 20.64%(759 cases).The dominant types were HPV52(6.53%,240 cases),HPV58(3.51%,129 cases),HPV16(2.99%,110 cases),HPV39(2.64%,97 cases)with HPV68(2.04%,75 cases).The lowest age range of HRHPV infection was 30~39 years old(18.10%,187 cases),the highest age range was 60~69 years old(37.61%,41 cases).The single-type infection rate in HRHPV infection mode was 14.11%(519 cases),the double infection rate was 4.81%(177 cases)and triple,quadruple and five-fold infections were detected.The infection rate of HRHPV(P<0.01)and infection pattern(P<0.05)were statistically different among different age groups.The female HRHPV infection types in Jingzhou are mainly HPV52,HPV58 and HPV16.The infection pattern is dominated by a single type of infection,followed by a double infection.Age was positively correlated with the positive rates and multiple infections of HRHPV.

关 键 词：人乳头状瘤病毒 高危型 基因分型 荆州地区 流行病学特征 

分 类 号：Q789[生物学—分子生物学] R18[医药卫生—流行病学]