血清S-100B蛋白联合NSE水平对新生儿缺氧缺血性脑病的预后评估价值  

Value of serum S-100B protein combined with NSE level in prognostic evaluation of neonatal hypoxic-ischemic encephalopathy

作　　者：陈小冰[1] 张雪梅[1] 陈求凝[1] 谢邦贵[1] 卢玉朱 CHEN Xiaobing;ZHANG Xuemei;CHEN Qiuning;XIE Banggui;LU Yuzhu(Department of Neonatology,the Third people′s Hospital of Hainan Province,Sanya,Hainan 572000,China)

机构地区：[1]海南省第三人民医院新生儿科,海南三亚572000

出　　处：《国际检验医学杂志》2020年第10期1175-1178,共4页International Journal of Laboratory Medicine

基　　金：海南省医药卫生科研基金项目(17A200517)。

摘　　要：目的探讨血清S-100B蛋白联合神经元特异性烯醇化酶(NSE)水平对新生儿缺氧缺血性脑病(HIE)的预后评估价值。方法选取该院收治的HIE患儿118例,根据其预后情况分为存活组(n=88)和死亡组(n=30)。采用神经症状临床分度分为轻中度组(n=82)和重度组(n=36),比较各组第1、3、5天血清S-100B蛋白及NSE水平变化。应用受试者工作特征曲线(ROC曲线)分析血清S-100B蛋白及NSE水平预测HIE患儿死亡的价值。结果死亡组第1、3、5天血清S-100B蛋白及NSE水平均明显高于存活组,且死亡组血清S-100B蛋白及NSE水平呈升高趋势(P<0.05)。重度组第1、3、5天血清S-100B蛋白及NSE水平均明显高于轻中度组,且重度组血清S-100B蛋白及NSE水平呈升高趋势(P<0.05)。ROC曲线显示,第3天血清S-100B蛋白联合NSE水平预测HIE患儿死亡的ROC曲线下面积最大为0.950(95%CI 0.892~0.997),其灵敏度和特异度分别为95.2%和89.6%。相关分析显示,死亡组血清S-100B蛋白与NSE水平呈正相关(r=0.817,P<0.01)。结论血清S-100B蛋白与NSE水平与HIE患儿的病情严重程度相关,第3天两项指标联合预测HIE患儿预后的价值较高。Objective To investigate the value of serum S-100B protein combined with neuron-specific enolase(NSE)in evaluating the prognosis of neonatal hypoxic-ischemic encephalopathy(HIE).Methods A total of 118 children with HIE who were treated in this hospital were selected and divided into survival group(n=88)and death group(n=30)according to their prognosis.According to the clinical classification of neurological symptoms were divided into mild to moderate group(n=82)and were severe group(n=36).The changes of serum S-100B protein and NSE levels on the 1,3,5 day of each group were compared.The receiver operating characteristic curve(ROC curve)was used to analyze the value of serum S-100B protein and NSE levels to predict the death of children with HIE.Results The levels of serum S-100B protein and NSE in the death group were significantly higher than those in the survival group on the 1,3,5 day,and the levels of serum S-100B protein and NSE in the death group showed an increasing trend(P<0.05).The levels of serum S-100B protein and NSE in the severe group were significantly higher than those in the mild to moderate group on the 1,3,5 day,and the serum S-100B protein and NSE levels in the severe group showed an increasing trend(P<0.05).The ROC curve showed that the area under the curve for predicting the death of children with HIE on the 3 day of serum S-100B protein combined with NSE level was 0.950(95%CI 0.892-0.997).The sensitivity and specificity were 95.2%and 89.6%,respectively.Correlation analysis showed that there was a positive correlation between serum S-100B protein and NSE level in the death group(r=0.817,P<0.01).Conclusion The levels of serum S-100B protein and NSE are related to the severity of the disease in children with HIE,and the combination of the two items on 3 day has a higher value in predicting the prognosis of children with HIE.

关 键 词：新生儿 缺氧缺血性脑病 S-100B蛋白 神经元特异性烯醇化酶 

分 类 号：R512[医药卫生—内科学]