正常清蛋白尿糖尿病肾病的认识及研究进展  

Recognition and research progress of normoalbuminuric diabetic kidney disease

作　　者：冯倩(综述) 俸家富(审校)[2] FENG Qian;FENG Jiafu(College of Medical Technology,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 611137,China;Department of Clinical Laboratory,Mianyang Central Hospital,Mianyang,Sichuan 621000,China)

机构地区：[1]成都中医药大学医学技术学院,四川成都611137 [2]绵阳市中心医院检验科,四川绵阳621000

出　　处：《国际检验医学杂志》2020年第10期1236-1241,共6页International Journal of Laboratory Medicine

基　　金：国家973计划子项目(2015CB755402-043);四川省科技支撑计划项目(2015SZ0117);四川省应用基础项目(2019YJ0701)。

摘　　要：糖尿病肾病(DKD)是糖尿病最主要的微血管并发症,同时也是导致糖尿病患者终末期肾病(ESKD)的主要原因。临床上,清蛋白尿被普遍认为是DKD从发生到发展至终末期肾病的最显著的临床症状之一,更是诊断DKD的主要依据。然而,近些年,越来越多的研究发现临床上有部分的糖尿病患者在发生肾损伤后,虽伴有肾小球滤过功能的减退,但仍然表现为“正常清蛋白尿”,即称为正常清蛋白尿DKD(NADKD)。文献检索显示,目前国内外对NADKD的相关研究报道较少,尚未引起临床的足够重视。该文就NADKD的定义、患病率、实验室检测、可能的分子机制及国内外研究现状进行综述。Diabetic kidney disease(DKD)is the most important microvascular complication of diabetes mellitus,and it is also the main cause of end-stage kidney disease(ESKD)in diabetic patients.Clinically,albuminuria is generally considered to be one of the most significant clinical symptoms of DKD from occurrence to progression to ESKD,and is the main basis for the diagnosis of DKD.However,more and more studies have found that a portion of diabetes patients in the clinic in recent years,have accompanied by glomerular filtration dysfunction after kidney injury,but still appear as"normal albuminuria",which is named normoalbuminuric DKD(NADKD).Literature search shows that there are few reports on the research of NADKD at home and abroad,and it has not yet attracted enough clinical attention.In this paper,the incidence,prevalence,laboratory testing,possible molecular mechanism and research statcs of NADKD were reviewed.

关 键 词：尿清蛋白肌酐比 糖尿病肾病 肾脏损伤 肾小球滤过率 

分 类 号：R446.1[医药卫生—诊断学]