鼠尾草酸的体内氧化应激调节作用研究进展  

Progress on Carnosic Acid as a Modulator of Oxidative Stress in Vivo

作　　者：罗成[1] 谭新敏 李艳[1] LUO Cheng;TAN Xin-min;LI Yan(School of Medicine,Yichun University,Yichun 336000,China)

机构地区：[1]宜春学院医学院,江西宜春336000

出　　处：《中国药学杂志》2020年第7期493-497,共5页Chinese Pharmaceutical Journal

基　　金：江西省自然科学基金项目资助(2016BAB215196);江西省教育厅科学技术项目资助(GJJ151021)。

摘　　要：氧化应激会破坏核酸、蛋白质和脂质等多种生物分子的结构和功能,导致基因表达调控、细胞信号转导、物质摄取及胞内运输等重要生命活动受到影响,是多种组织器官发生病变的主要因素。鼠尾草酸富含于迷迭香等植物中,能够活化细胞内抗氧化系统[如核转录因子E2相关因子2-BTB-Kelch样ECH相关蛋白1(nuclear factor erythroid-2 related factor 2-BTB-Kelch-like ECH-associated protein 1,Nrf2-Keap1)、沉默交配型信息调节因子2同源蛋白1(silent mating type information regulation 2 homolog 1,Sirt1)等信号通路]清除活性氧,同时抑制其他促进氧化应激的信号通路[如核转录因子κB(nuclear factor-kappa B,NF-κB)、糖基化终末产物(advanced glycation end products,AGE)等],抑制活性氧的作用,最终减缓甚至阻止氧化应激,有效预防和治疗如神经系统、视网膜、心血管、肝脏等组织器官的病变。笔者整理归纳了鼠尾草酸对氧化应激相关疾病的调节机制,为推进鼠尾草酸临床应用的转化提供参考。Oxidative stress could destroy the structures and functions of many biological molecules(such as nucleic acids,proteins,lipids)and undermine many physiological activities,such as gene expression regulation,cell signal transduction,substance uptake and intracellular transport,thus leading to many tissue and organ pathological damages.Carnosic acid,rich in rosemary(Rosmarinus officinalis L.),could retard or prevent oxidative stress by activating the cellular antioxidant system(such as Nrf2-Keap1,Sirt1 signaling pathway)or inhibiting pro-oxidant signaling pathways(such as NF-κB,AGEs,etc.)to scavenge reactive oxygen species.It exhibits favorable effects on the prevention and treatment of oxidative stress-related diseases involving nervous system,retina,cardiovascular,liver,etc.The modulation mechanisms of carnosic acid on these diseases are summarized in this review,which shall provide a reference for promoting the clinical applications of carnosic acid.

关 键 词：鼠尾草酸 氧化应激 核转录因子E2相关因子2 沉默交配型信息调节因子2同源蛋白1 核转录因子ΚB 

分 类 号：R965[医药卫生—药理学]