器官发育与再生的细胞谱系建立机制  

The Mechanisms of Cell Lineage Establishment for Organ Development and Regeneration

作　　者：赵天宇 李礼 孟庆峰[3] 冯雪莲[4] 田艳艳[4] Zhao Tianyu;Li Li;Meng Qingfeng;Feng Xuelian;Tian Yanyan(Chongqing Medical University,Chongqing400016;Southwest University,Chongqing400715;Bureau of Policy,National Natural Science Foundation of China,Beijing100085;Department of Life Sciences,National Natural Science Foundation of China,Beijing100085)

机构地区：[1]重庆医科大学,重庆400016 [2]西南大学,重庆400715 [3]国家自然科学基金委员会政策局,北京100085 [4]国家自然科学基金委员会生命科学部,北京100085

出　　处：《中国科学基金》2020年第2期221-227,共7页Bulletin of National Natural Science Foundation of China

摘　　要：在第198期双清论坛上,专家围绕"器官发育与再生的细胞和分子基础"这一主题,从分子机制、技术方法应用、学科交叉等不同层面、角度探讨了器官发育与再生相关的细胞谱系的研究背景、主要进展、现阶段的主要瓶颈及新技术与新方法对推进细胞谱系研究的作用等重要内容。与会专家一致认为细胞谱系研究是器官发育与再生的研究核心,利用新技术和新方法推进细胞谱系研究对于器官发育与再生研究领域意义重大。论坛主要从以下6个方面凝练了器官发育与再生研究领域关键科学问题:(1)细胞谱系示踪和实时追踪新方法与新模型的建立;(2)器官发育的细胞谱系图谱绘制;(3)器官发育的细胞谱系建立机制;(4)器官发育异常的细胞谱系建立缺陷及病理机制;(5)器官再生的细胞谱系建立及其调控机制;(6)植物器官发育与再生中位置效应调控细胞谱系及机制。在现有的研究基础上,通过发挥国内多学科交叉的优势组织协同研究,并在新技术与新方法方面大力创新,必将进一步推进器官发育与再生研究领域的进展,为最终探明器官发育与再生的分子机理、预防和治疗临床相关疾病、造福人类社会提供坚实保障。The 198th Shuangqing Forum entitled"Cellular and Molecular basis of Organ Development and Regeneration"was held in Chongqing on April 26-27,2018.This forum was sponsored by the National Natural Science Foundation of China and organized with the generous help of Southwest University.More than 40 scholars from 20 research institutions and universities attended the forum.They presented the latest research progress in the area of organ development and regeneration covering novel molecular mechanism,newly developed technology and interdisciplinary system.After thoroughly discussion,they concluded that the developing cell lineage conceals the essential information for regeneration and deciphering the cell lineage code with new technology will generate a significantly impact on both organ development and regeneration study.In the forum,6 highlighted scientific issues were proposed:(1)establish novel model system for cell lineage tracing and real-time observation;(2)map the developing whole organ cell lineage;(3)approach the detailed mechanism behind cell lineage establishment;(4)disclose the mechanism of the defective cell lineage on abnormal organ development or disease;(5)investigate the replacement cells origin and map their lineage during organ regeneration;(6)explore the detailed cell lineage during plant organ development and regeneration. With innovation on both technology and methodology,our scientists would make great breakthrough in both fundamental research and clinical applications regarding organ development and regeneration.

关 键 词：器官发育 器官再生 细胞谱系 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]