龙胆泻肝汤联合针刺治疗肝经湿热型早泄临床研究  

Clinical Study on Longdan Xiegan Tang Combined with Acupuncture for Premature Ejaculation of Dampness-heat in Liver Meridian Type

作　　者：唐梁[1] 刘晓俊[1] 李世林[2] TANG Liang;LIU Xiaojun;LI Shilin

机构地区：[1]广州市第一人民医院中医科,广东广州511457 [2]广州市第一人民医院泌尿外科,广东广州511457

出　　处：《新中医》2020年第7期37-40,共4页New Chinese Medicine

基　　金：刘晓俊广州市名中医传承工作室建设项目(ky01050002)。

摘　　要：目的:探讨龙胆泻肝汤联合针刺治疗肝经湿热型早泄的临床疗效及可能作用机制。方法:选取本院泌尿外科及中医科门诊就诊的符合诊断标准的早泄患者120例,随机分为A、B、C、D4组,每组各30例,分别给予舍曲林、针刺、龙胆泻肝汤、龙胆泻肝汤加针刺治疗。治疗周期为4周。4组均于治疗前后进行射精潜伏期(IELT)、患者性生活满意度评分、配偶性生活满意度评分、睾酮检测及药物安全性评估。结果:各组IELT于治疗结束后均延长,差异有统计学意义(P<0.05)。同时,组间比较治疗结束后D组IELT明显高于其余各组,差异有统计学意义(P<0.05)。各组患者、配偶性生活满意度评分治疗后均比治疗前提高,差异有统计学意义(P<0.05)。组间比较,治疗后D组患者、配偶性生活满意度评分均比A组、B组、C组高,差异有统计学意义(P<0.05)。治疗前,各组血清睾酮水平比较,差异无统计学意义(P> 0.05)。各组治疗后血清睾酮水平较治疗前均下降,差异均有统计学意义(P<0.05)。治疗后C组、D组较A组、B组血清睾酮水平低,差异有统计学意义(P<0.05)。治疗期间各组不良反应经治疗均消失,安全指标未见明显异常。结论:龙胆泻肝汤联合针刺治疗可改善肝经湿热型早泄的症状,安全、有效,其作用可能与中药对血清睾酮的调节有关。Objective: To discuss the clinical effect of Longdan Xiegan tang combined with acupuncture for premature ejaculation of dampness-heat in the liver meridian type and its possible mechanism. Methods: A total of 120 cases of patients with premature ejaculation in our Urinary Surgery Department and Chinese Medicine Clinic and in accordance with the diagnosis criteria were selected and randomly divided into group A,B,C and D,30 cases in each group. Each group was treated with sertraline,acupuncture,Longdan Xiegan tang,and the combination of Longdan Xiegan tang and acupuncture respectively. All groups were treated for four weeks. Before and after treatment,intravaginal Ejaculation Latency Time(IELT),the satisfaction score of the sexual life of both patients and their spouses,test for testosterone and medicine safety were evaluated in all the four groups. Results: The IELT in each group was prolonged after treatment, the difference being significant(P<0.05). Meanwhile,after treatment,the IELT in group D was significantly longer than that in the other groups respectively, the difference being significant(P<0.05). After treatment, the satisfaction scores of the sexual life of both patients and their spouses in each group were increased when compared with those before treatment respectively, the difference being significant(P<0.05);after treatment,the above scores in group D,group C were higher than those in group A and B,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of the levels of testosterone in serum among the four groups(P>0.05). After treatment, the levels of testosterone in serum in all groups were decreased when compared with those before treatment, differences being significant(P<0.05). After treatment,the level of testosterone in serum in group D was lower than those in group A and group B respectively,the difference being significant(P<0.05). During treatment,the adverse reactions in all groups disappeared after treatment,with no obv

关 键 词：早泄 肝经湿热型 龙胆泻肝汤 针刺 舍曲林 睾酮 

分 类 号：R698[医药卫生—泌尿科学] R245.31[医药卫生—外科学]