芪参益气滴丸联合琥珀酸美托洛尔治疗慢性心力衰竭临床研究  

Study on Qishen Yiqi Dropping Pills Combined with Metoprolol Succinate for Chronic Heart Failure

作　　者：吕毅[1] 郭强[1] 岳龙 LYU Yi;GUO Qiang;YUE Long

机构地区：[1]华亭县中医医院,甘肃华亭744100

出　　处：《新中医》2020年第7期58-60,共3页New Chinese Medicine

摘　　要：目的:观察芪参益气滴丸联合琥珀酸美托洛尔治疗慢性心力衰竭的临床疗效。方法:将102例慢性心力衰竭患者随机分为观察组与对照组,每组各51例;对照组给予常规地高辛、螺内酯治疗,观察组给予芪参益气滴丸联合琥珀酸美托洛尔治疗,观察比较2组临床疗效、不良反应,以及治疗前后左室射血分数(LEVF)、左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)指标变化。结果:治疗后,总有效率观察组为98.04%,对照组为82.35%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者LEVF值较治疗前明显升高(P<0.05),LVEDD、LVESD值较治疗前明显降低(P<0.05);且观察组各项指标改善较对照组更显著(P<0.05)。不良反应发生率观察组为3.92%,对照组为21.57%,2组比较,差异有统计学意义(P<0.05)。结论:芪参益气滴丸联合琥珀酸美托洛尔治疗慢性心力衰竭疗效优于地高辛联合螺内酯治疗,能有效改善心功能,且安全性良好,值得临床推广应用。Objective:To observe the clinical effect of Qishen Yiqi dropping pills combined with metoprolol succinate for chronic heart failure. Methods: A total of 102 cases of patients with chronic heart failure were randomly divided into the observation group and the control group,51 cases in each group. The control group was routinely treated with digoxin and spironolactone,and the observation group was treated with Qishen Yiqi dropping pills combined with metoprolol succinate.The clinical effect, the adverse reactions and the changes of left ventricular ejection fraction(LVEF), left ventricular enddiastolic dimension(LVEDD) and left ventricular end-systolic diameter(LVESD) before and after treatment in the two groups were observed and compared. Results:After treatment,the total effective rate was 98.04% in the observation group and82.35% in the control group,the difference being significant(P<0.05). After treatment,the values of LVEF in the two groups were significantly increased when compared with those before treatment(P<0.05), and the values of LVEDD and LVESD were significantly decreased when compared with those before treatment(P<0.05);the improvement of the indexes in the observation group was more significant when compared with that in the control group(P<0.05). The incidence of adverse reactions was 3.92% in the observation group and 21.57% in the control group, the difference being significant(P<0.05).Conclusion: Compared with that of digoxin and spironolactone, the therapy of Qishen Yiqi dropping pills combined with metoprolol succinate has better curative effect in treating chronic heart failure, which can effectively improve the heart function with good safety and is worthy of clinical application and promotion.

关 键 词：慢性心力衰竭 中西医结合疗法 芪参益气滴丸 琥珀酸美托洛尔 

分 类 号：R541.6[医药卫生—心血管疾病]