中药汤剂联合体外震波碎石术治疗肾结石临床研究  

Clinical Study on Chinese Herbal Decoction Combined with Extracorporeal Shock Wave Lithotripsy for Renal Calculi

作　　者：祝秀文[1] 童炎岳[1] 万里军[1] ZHU Xiuwen;TONG Yanyue;WAN Lijun

机构地区：[1]衢州市人民医院泌尿外科,浙江衢州324000

出　　处：《新中医》2020年第7期80-83,共4页New Chinese Medicine

摘　　要：目的:分析中药汤剂联合体外震波碎石术(ESWL)治疗肾结石的临床疗效以及对肾功能、炎症因子、尿液代谢的影响。方法:选择肾结石患者124例,按随机数字表法分为观察组和对照组各62例。2组患者均采用ESWL治疗,术后,对照组给予常规药物处理,观察组在对照组基础上给予中药排石汤治疗。比较2组临床疗效、肾功能指标[尿素氮(BUN)、血肌酐(SCr)和胱抑素C(Cys C)]、炎症因子水平[肿瘤坏死因子-α(TNF-α)、白细胞介素-2 (IL-2)、白细胞介素-6 (IL-6)]及尿液代谢异常发生率。结果:观察组总有效率为95.16%,高于对照组77.42%(P<0.05)。术前,2组BUN、SCr和Cys C水平比较,差异无统计学意义(P>0.05)。术后,对照组BUN、SCr和Cys C水平较术前均显著升高(P<0.05);而观察组BUN、SCr和Cys C水平较术前无明显变化(P>0.05),但是术后各项指标低于对照组(P<0.05)。术前,2组TNF-α、IL-2和IL-6水平比较,差异无统计学意义(P>0.05)。术后,2组TNF-α、IL-2和IL-6水平较术前均显著升高(P<0.05),而观察组TNF-α、IL-2和IL-6水平显著低于对照组(P<0.05)。术后,观察组尿液代谢异常发生率为3.23%,低于对照组25.81%(P<0.05)。结论:中药汤剂联合ESWL不仅显著提高肾结石的治疗效果,有效改善肾功能,而且能够降低炎症反应和尿液代谢异常发生率,具有较好的临床应用价值。Objective:To analyze the clinical effect of Chinese herbal decoction combined with extracorporeal shock wave lithotripsy(ESWL) for patients with renal calculi,and its effect on renal function,inflammatory factors and urinary metabolism.Methods: Selected 124 cases of patients with renal calculi, and divided them into the observation group and the control group according to random number table, 62 cases in each group. Both groups received ESWL for treatment. After operation, the control group received routine medical treatment, while the observation group additionally received Paishi tang. Compared the clinical effect, the indexes of renal function [blood urea nitrogen(BUN), serum creatinine(SCr) and cystatin C(Cys C)],the levels of inflammatory factors [tumor necrosis factor-α(TNF-α),interleukin-2(IL-2) and interleukin-6(IL-6)] and the incidence of abnormal urinary metabolism. Results:The total effective rate was 95.16% in the observation group,being higher than 77.42% in the control group(P<0.05). Before operation,there was no significant difference being found when comparing the levels of BUN,SCr and Cys C in the two groups(P>0.05). After operation,the levels of BUN,SCr and Cys C in the control group were significantly increased when compared with those before operation(P<0.05);there was no significant difference being found when comparing the levels of BUN,SCr and Cys C in the observation group with those before operation(P>0.05),but each index above was lower than that in the control group(P<0.05). Before operation,there was no significant difference being found when comparing the levels of TNF-α,IL-2 and IL-6 in the two groups(P>0.05). After operation, the levels of TNF-α, IL-2 and IL-6 in both groups were significantly higher than those before treatment(P<0.05),but the levels of TNF-α,IL-2 and IL-6 in the observation group were significantly lower than those in the control group(P<0.05). After operation, the incidence of abnormal urinary metabolism was 3.23% in the observation group,being lower than 25.

关 键 词：肾结石 中药汤剂 体外震波碎石术 肾功能 炎症因子 尿液代谢异常 

分 类 号：R692.4[医药卫生—泌尿科学]