宫外孕方联合甲氨蝶呤对未破裂型输卵管妊娠患者β-HCG、CK、P水平及盆腔部包块的影响  

Effect of Prescription for Ectopic Pregnancy Combined with Methotrexate on the Level of β-HCG,CK,and P and Pelvic Mass in Patients with Non-ruptured Tubal Pregnancy

作　　者：颜晓钏[1] 卢亦彬[1] 马大正[1] YAN Xiaochuan;LU Yibin;MA Dazheng

机构地区：[1]温州市中医院中医妇科,浙江温州325000

出　　处：《新中医》2020年第7期106-109,共4页New Chinese Medicine

基　　金：温州市科技计划经费自筹项目(Y20160347)。

摘　　要：目的:探讨宫外孕方联合甲氨蝶呤对未破裂型输卵管妊娠患者β-人绒毛膜促性腺激素(β-HCG)、肌酸激酶(CK)、孕酮(P)水平及盆腔部包块影响。方法:将134例未破裂型输卵管妊娠患者按随机数字表法分成对照组67例给予常规西医治疗,观察组67例在对照组基础上加服宫外孕方。随访2年,观察临床疗效、盆腔包块、血清因子、输卵管通畅度及宫内受孕情况。结果:观察组治愈92.54%,对照组治愈79.10%,差异有统计学意义(P<0.05)。治疗后,2组包块直径及血清因子较前改善(P<0.05);观察组包块直径、血清CK、β-HCG含量较对照组下降,血清P含量较对照组升高(P<0.05)。观察组治愈患者通畅率为90.32%,对照组为73.58%,2组比较,差异有统计学意义(P<0.05)。治疗后,随访2年,观察组患者宫内妊娠时间、自然流产、再次异位妊娠及继发性不孕比例低于对照组,足月分娩比例高于对照组(P<0.05)。结论:宫外孕方联合甲氨蝶呤对未破裂型输卵管妊娠患者疗效理想,可加速其症状消退,改善患者输卵管与生殖功能。Objective: To discuss the effect of prescription for ectopic pregnancy combined with methotrexate on the expression of β-human chorionic gonadotropin(β-HCG),creatine kinase(CK) and progesterone(P) and pelvic mass in patients with non-ruptured tubal pregnancy. Methods: Divided 134 cases of patients with non-ruptured tubal pregnancy into the control group and the observation group according to random number table, 67 cases in each group. The control group received routine western medicine treatment, while the observation group additionally received prescription for ectopic pregnancy. The follow-ups lasted for two years. Observed the clinical effect,pelvic mass,serum factors,tubal patency and the status of intrauterine pregnancy. Results: The healing rate was 92.54% in the observation group and 79.10% in the control group, difference being significant(P<0.05). After treatment, the diameters of mass and serum factors in both groups were improved when compared with those before treatment;the diameters of mass and the contents of serum CK and β-HCG in the observation group were lower than those in the control group,and the content of serum P was higher than that in the control group(P<0.05). The patency rate for the cured patients was 90.32% in the observation group and 73.58% in the control group, difference being significant(P < 0.05). After treatment, the follow-ups lasted for two years. The intrauterine pregnancy time and the proportions of spontaneous abortion, repetition of ectopic pregnancy and secondary infertility in the observation group were lower than those in the control group,and the proportion of term delivery was higher than those in the control group(P<0.05). Conclusion: The application of prescription for ectopic pregnancy combined with methotrexate has good therapeutic effect in treating patients with non-ruptured tubal pregnancy,which can accelerate the remission of symptoms and improve tubal and reproductive functions.

关 键 词：输卵管妊娠 未破裂型 宫外孕方 甲氨蝶呤 盆腔包块 Β-人绒毛膜促性腺激素 

分 类 号：R714.221[医药卫生—妇产科学]