姜黄素通过NF-κB信号通路调控椎间盘退行性改变研究进展  

Research Progress of Curcumin Regulating Intervertebral Disc Disease through NF-κB Signaling Pathway

作　　者：王国强 张英健 董黎强 安忠诚 WANG Guoqiang;ZHANG Yingjian;DONG Liqiang;AN Zhongcheng

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属第二医院,浙江杭州310005

出　　处：《新中医》2020年第8期13-16,共4页New Chinese Medicine

摘　　要：椎间盘退行性改变(IVDD)与核转录因子κB(NF-κB)信号通路密切相关,姜黄素可通过抑制NF-κB通路干预IVDD的影响因素来减缓其退变过程。笔者结合文献就参与NF-κB信号通路调控IVDD的相关因素和以姜黄素为代表的NF-κB抑制剂干预IVDD的相关研究进展进行综述。Intervertebral disc disease(IVDD)is closely related to nuclear factorκB(NF-κB)signaling pathway.Curcumin can inhibit NF-κB signaling pathway to intervene the influencing factors of IVDD,so that the degeneration process can be slowed down.Based on literature,the authors reviewed the related factors involved in the regulation of IVDD by NF-κB signaling pathway,and the related research progress of intervention of IVDD by NF-κB inhibitors represented by curcumin.

关 键 词：椎间盘退行性改变 姜黄素 核转录因子ΚB 文献综述 

分 类 号：R681.53[医药卫生—骨科学]