人类冠状病毒概况及其药物治疗研究进展  

Research progress on human coronavirus and antiviral drugs

作　　者：王子民 王雪雅 荆晓光 远东涛[1] 宛磊[1] 李智浩[1] 吴大龙 张世魁 王斌[1] 宋松根 武娜[3] 魏茜[4] Wang Zi-Min;Wang Xue-Ya;Jing Xiao-Guang;Yuan Dong-Tao;Wan Lei;Li Zhi-Hao;Wu Da-Long;Zhang Shi-Kui;Wang Bin;Song Song-Gen;Wu Na;Wei Qian(Laboratory of Trauma Repair Engineering,the Second Affiliated Hospital of Luohe Medical College,Luohe,Henan 462000,China;Department of Pharyngology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Medical Insurance Office of the First Medical Center of PLA General Hospital,Beijing 100853,China;Research Center for Tissue Repair and Regeneration,Beijing Key Research Laboratory of Skin Injury,Repair and Regeneration,Innovative Medical Research Department of Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]漯河医学高等专科学校第二附属医院创伤修复工程实验室,河南漯河462000 [2]郑州大学第一附属医院咽喉科,郑州450052 [3]解放军总医院第一医学中心医疗保险办公室,北京100853 [4]解放军总医院创新研究部创伤修复与组织再生研究室,北京100048

出　　处：《解放军医学杂志》2020年第4期375-383,共9页Medical Journal of Chinese People's Liberation Army

摘　　要：冠状病毒(CoV)主要在鸟类和哺乳动物中引起局部感染,最近几十年,已有证据显示其可感染人类。高致病性冠状病毒[包括严重急性呼吸综合征冠状病毒(SARS-CoV)、中东呼吸综合征冠状病毒(MERS-CoV)]是人畜共患病毒,对公共卫生构成重大威胁。严重急性呼吸综合征冠状病毒2(SARS-CoV-2)通过密切接触在人与人之间传播所引起的新型冠状病毒肺炎(COVID-19)已经严重威胁人类的健康和安全,部分患者可发展为急性呼吸窘迫综合征和多脏器衰竭,发病率及病死率均较高。该文就冠状病毒的结构、流行病学、免疫学以及治疗药物进行综述,希望能为本病的预防、控制和治疗提供参考。Coronavirus mainly causes local infection in birds and mammals.In recent decades,there has been an evidence that it can infect humans.Highly pathogenic coronavirus,including severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV),are fatal zoonotic viruses,which have posed a major threat to public health.Severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2,COVID-19)has also seriously endangered the health and safety of the human beings.These coronaviruses transmit through close contact between people,resulting in the development of acute respiratory distress syndrome(ARDS)and multiple organ failure(MOF)and having a higher morbidity and mortality.This article reviews the structure,epidemiology,immunology and treatment of the coronavirus,hoping to provide reference for the prevention,control and treatment of the disease.

关 键 词：冠状病毒 严重急性呼吸综合征 中东呼吸综合征 严重急性呼吸综合征冠状病毒2 流行病学 瑞德西韦 环孢素A 

分 类 号：R373.1[医药卫生—病原生物学]