NA单药及序贯联合Peg干扰素对慢乙肝患者CD11c+mDC功能的影响  

Effects of NA Monotherapy and Sequential combination of Peg Interferon on CD11c+mDC Function in CHB Patients

作　　者：杜景华 张影 徐慧宁 DU Jing-hua;ZHANG Ying;XU Hui-ning(Dalian Sixth People's Hospital,Dalian 116000,China)

机构地区：[1]大连市第六人民医院,辽宁大连116000

出　　处：《中国医药指南》2020年第13期40-41,共2页Guide of China Medicine

基　　金：大连市医学科学研究计划项目资助(项目编号:1711053)

摘　　要：目的探讨NA单药及序贯联合Peg干扰素对慢乙肝患者CD11c+mDC功能的影响。方法收集我院接受NA单药治疗和序贯Peg干扰素患者基线,治疗24周及治疗48周时的外周血各10 mL(单药及序贯组各20 mL);并选取健康对照10例。进行外周血mDC频数检测及外周血流式细胞仪检测髓样树突状细胞mDC表面共刺激分子CD80、CD86的表达。结果序贯联合组外周血mDC占PBMC百分比明显高于单药治疗组(P<0.05),序贯联合组mDC表面共刺激分子CD80、CD86的表达率高于单药治疗(P<0.05)。结论NA序贯联合Peg干扰素可以提高CD11c+mDC的功能,激活天然免疫,启动更持久的适应性免疫。Objective To investigate the effect of NA monotherapy and sequential combination of Peg interferon on CD11c+mDC function in CHB patients.Methods 10 mL of peripheral blood(20 mL of the monotherapy and sequence group)of patients receiving NA monotherapy and sequential Peg interferon were collected at baseline at 24 weeks and 48 weeks of treatment.And selected healthy control 10 cases.Peripheral blood mDC frequency and peripheral blood flow cytometer were used to detect the expression of mDC surface costimulatory molecular CD80,CD86 of myeloid dendritic cells.Results The percentage of peripheral blood mDC in the sequential combined group was significantly higher than that in the single drug treatment group(P<0.05),and the expression rate of surface costimulatory molecular CD80,CD86 in the sequential combined group was higher than that in the single drug treatment group(P<0.05).Conclusions NA sequential combination Peg interferon can improve CD11c mDC function,activate innate immunity and initiate more durable adaptive immunity.

关 键 词：NA Peg干扰素 慢性乙型肝炎 CD11c+mDC 

分 类 号：R512.6+2[医药卫生—内科学]