磷酸肌酸钠辅助治疗新生儿窒息的效果及对心肌酶指标的影响  

Effects of Creatine Phosphate Sodium Adjuvant Therapy on Neonatal Asphyxia and its Influence on Myocardial Enzymes Indexes

作　　者：马洪丹 MA Hong-dan(Department of Neonatology,Tieling Maternal and Child Hospital,Tieling 112000,China)

机构地区：[1]铁岭市妇婴医院新生儿科,辽宁铁岭112000

出　　处：《中国医药指南》2020年第13期131-132,共2页Guide of China Medicine

摘　　要：目的研究磷酸肌酸钠辅助治疗新生儿窒息的疗效,并分析该药物对心肌酶指标的影响。方法选取本院2016年3月至2019年3月收治的90例窒息新生儿,按照随机表法将患者分为观察组和对照组,每组各45例。对照组给予盐酸多巴胺单药治疗,观察组给予盐酸多巴胺+磷酸肌酸钠联合治疗。观察组和对照组均在治疗前后测定患儿的心肌酶指标,在治疗3周后测定新生儿行为神经(NBNA)评分,并评价其疗效和安全性。结果①在NBNA评分方面,观察组为(66.32±4.78)分,显著高于对照组的(53.49±3.55)分(t=20.451,P<0.05);②在心肌酶指标方面,治疗后观察组和对照组的α-羟丁酸脱氢酶(HBDH)、磷酸激酸激酶同工酶(CKMB)、心肌酶肌酸激酶(CK)、乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)比治疗前均有所下降,且观察组治疗后分别为(186.64±26.78)U/L、(27.13±7.41)U/L、(403.57±32.89)U/L、(288.65±27.89)U/L、(32.42±6.23)U/L,显著低于对照组的(211.34±24.86)U/L、(37.51±8.83)U/L、(426.21±37.67)U/L、(308.47±29.99)U/L、(41.96±8.55)U/L(t=4.535、6.041、3.037、3.248、6.056,P均<0.05);③在治疗效果方面,观察组97.78%高于对照组80.0%(χ~2=7.200,P<0.05);④在不良反应发生率方面,观察组6.67%低于对照组17.78%,差异有统计学意义(χ2=0.040,P>0.05)。结论磷酸肌酸钠能在辅助治疗新生儿窒息中取得很好的疗效,且用药安全。Objective To study the effects of creatine phosphate sodium adjuvant therapy in the treatment of neonatal asphyxia and analyze the influence of the drug on myocardial enzymes indexes.Methods A total of 90 asphyxia neonates admitted to the hospital from March 2016 to March 2019 were selected and divided into observation group and control group according to the random table method,with 45 cases in each group.Control group was given dopamine hydrochloride monotherapy,and observation group was given dopamine hydrochloride+creatine phosphate sodium.The myocardial enzymes indexes were measured before and after treatment between observation group and control group.The neonatal behavioral neurological assessment(NBNA)score was measured after 3 w of treatment,and the efficacy and safety were evaluated.Results①The NBNA score in observation group was significantly higher than that in control group[(66.32±4.78)points vs(53.49±3.55)points](t=20.451,P<0.05).②In terms of myocardial enzymes indexes,the levels ofα-hydroxybutyrate dehydrogenase(HBDH),phosphokinase isoenzyme(CKMB),myocardial enzyme creatine kinase(CK),lactate dehydrogenase(LDH)and aspartate aminotransferase(AST)in observation group and control group after treatment were decreased compared with those before treatment.And the levels after treatment were(186.64±26.78)U/L,(27.13±7.41)U/L,(403.57±32.89)U/L,(288.65±27.89)U/L and(32.42±6.23)U/L in observation group,which were significantly lower than those in control group with(211.34±24.86)U/L,(37.51±8.83)U/L,(426.21±37.67)U/L,(308.47±29.99)U/L and(41.96±8.55)U/L(t=4.535,6.041,3.037,3.248,6.056,all P<0.05).③The treatment effect in observation group was higher than that in control group(97.78%vs 80.0%)(χ2=7.200,P<0.05).④The incidence rate of adverse reactions in observation group was lower than that ib control group(6.67%vs 17.78%)(χ~2=0.040,P>0.05).Conclusion Creatine phosphate sodium can achieve good efficacy in the treatment of neonatal asphyxia,and it is safe to use.

关 键 词：新生儿窒息 磷酸肌酸钠 心肌酶 

分 类 号：R722.12[医药卫生—儿科]