肝硬化上消化道出血治疗中生长抑素的应用及效果评定  

Application and Effect Evaluation of Somatostatin in the Treatment of Upper Gastrointestinal Hemorrhage Due to Cirrhosis

作　　者：王超 WANG Chao(Department of Gastroenterology,Fukuang General Hospital of Liaoning Health Industry Group,Fushun 113008,China)

机构地区：[1]辽宁省健康产业集团抚矿总医院消化内科,辽宁抚顺113008

出　　处：《中国医药指南》2020年第13期153-154,共2页Guide of China Medicine

摘　　要：目的探讨肝硬化上消化道出血治疗中生长抑素的应用及效果。方法纳入我院60例2017年2月至2018年12月肝硬化上消化道出血患者。随机数字表分组,奥曲肽治疗组对于就诊的肝硬化上消化道出血患者采取奥曲肽等常规药物治疗,生长抑素辅助治疗组对于就诊的肝硬化上消化道出血患者采取奥曲肽联合生长抑素治疗。比较奥曲肽治疗组、生长抑素辅助治疗组疗效;肝硬化上消化道出血止血的时间、肝硬化上消化道失血量、平均输血量;治疗前后患者平均血红蛋白监测值、生命质量评分;再出血、电解质紊乱、肝性脑病等并发症。结果生长抑素辅助治疗组疗效、肝硬化上消化道出血止血的时间、肝硬化上消化道失血量、平均输血量、平均血红蛋白监测值、生命质量评分相比较奥曲肽治疗组更好,P<0.05。生长抑素辅助治疗组再出血、电解质紊乱、肝性脑病等并发症和奥曲肽治疗组无明显差异,P>0.05。结论奥曲肽联合生长抑素治疗肝硬化上消化道出血的效果确切,可有效促进上消化道止血,减少失血量和输血量,更好维持电解质平衡和血红蛋白稳定,减少并发症的发生,改善患者的生命质量。Objective To investigate the application and effect of somatostatin in the treatment of upper gastrointestinal hemorrhage due to cirrhosis.Methods Sixty patients with cirrhosis of upper gastrointestinal hemorrhage from February 2017 to December 1818 were enrolled in our hospital.Randomized digital table grouping,octreotide treatment group for patients with cirrhosis of upper gastrointestinal hemorrhage taking octreotide and other conventional drugs,somatostatin adjuvant treatment group for patients with cirrhosis of upper gastrointestinal bleeding patients with octreotide combined with somatostatin treatment.Comparison of octreotide treatment group,somatostatin adjuvant treatment group;cirrhosis upper gastrointestinal bleeding hemostasis time,cirrhosis upper gastrointestinal tract blood loss,average blood transfusion volume;mean hemoglobin monitoring value and quality of life score before and after treatment;rebleeding,Complications such as electrolyte imbalance and hepatic encephalopathy.Results The efficacy of the somatostatin-assisted treatment group,the time of hemostasis of cirrhosis with upper gastrointestinal hemorrhage,the upper gastrointestinal cirrhosis,the mean blood transfusion,the mean hemoglobin monitoring value,and the quality of life score were better than the octreotide treatment group,P<0.05.There were no significant differences in complications such as rebleeding,electrolyte imbalance,hepatic encephalopathy and octreotide treatment in the adjuvant treatment group(P>0.05).Conclusion Octreotide combined with somatostatin is effective in treating upper gastrointestinal hemorrhage of liver cirrhosis,which can effectively promote upper gastrointestinal hemostasis,reduce blood loss and blood transfusion,better maintain electrolyte balance and hemoglobin stability,reduce complications and improve patients.Quality of life.

关 键 词：肝硬化上消化道出血 生长抑素 应用效果 

分 类 号：R657.3+1[医药卫生—外科学] R573.2[医药卫生—临床医学]