不同病情程度妊娠期高血压患者的凝血功能指标和血小板参数分析  

Analysis of coagulation function indexes and platelet parameters in patients with different degrees of gestational hypertension

作　　者：许林波 王蓓[2] XU Lin-bo;WANG Bei(Medical Laboratory Center,Northwest Women and Children's Hospital,Xi'an 710061;Central Laboratory,Xi'an Children's Hospital,Xi'an 710043,China)

机构地区：[1]西北妇女儿童医院医学检验中心,陕西西安710061 [2]西安市儿童医院中心实验室,陕西西安710043

出　　处：《临床医学研究与实践》2020年第14期112-114,共3页Clinical Research and Practice

摘　　要：目的分析不同病情程度妊娠期高血压患者的凝血功能指标和血小板参数。方法选取2017年10月至2019年10月收治的100例妊娠期高血压患者作为观察组[包括妊娠期高血压组(46例)、轻度子痫前期组(28例)和重度子痫前期组(26例)],另选取同期100例正常待产孕妇作为对照组。比较各组受检者的凝血功能指标[纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、血浆凝血酶原时间(PT)]和血小板参数[血小板分布宽度(PDW)、血小板平均体积(MPV)、血小板计数(PLT)]。结果观察组的FIB水平高于对照组,APTT、TT、PT均短于对照组,差异具有统计学意义(P<0.05)。重度子痫前期组的FIB水平高于轻度子痫前期组和妊娠期高血压组,APTT、TT、PT均短于轻度子痫前期组和妊娠期高血压组,差异具有统计学意义(P<0.05)。观察组的PDW、MPV大于对照组,PLT小于对照组,差异具有统计学意义(P<0.05)。重度子痫前期组的PDW、MPV大于轻度子痫前期组和妊娠期高血压组,PLT小于轻度子痫前期组和妊娠期高血压组,差异具有统计学意义(P<0.05)。结论妊娠期高血压患者均存在凝血功能障碍和血小板活化现象,加强凝血功能指标和血小板参数监测,能够对妊娠期高血压患者病情程度起到预判作用,进而保障母婴健康。Objective To analyze the coagulation function indexes and platelet parameters in patients with different degrees of gestational hypertension.Methods From October 2017 to October 2019,100 patients with gestational hypertension were selected as observation group[including pregnancy hypertension group(46 cases),mild preeclampsia group(28 cases)and severe preeclampsia group(26 cases)],and 100 normal pregnant women in the same period were selected as control group.The coagulation function indexes[fibrinogen(FIB),activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT)]and platelet parameters[platelet distributionwidth(PDW),mean platelet volume(MPV),platelet count(PLT)]of subjects in each group were compared.Results The FIB level in the observation group was higher than that in the control group,APTT,TT and PT were shorter than those in the control group,and the differences were statistically significant(P<0.05).The FIB level in the severe preeclampsia group was higher than that in the mild preeclampsia group and the pregnancy hypertension group,APTT,TT and PT were shorter than those in the mild preeclampsia group and the pregnancy hypertension group,and the differences were statistically significant(P<0.05).PDW and MPV in the observation group were higher than those in the control group,and PLT was lower than that in the control group,and the differences were statistically significant(P<0.05).PDW and MPV in the severe preeclampsia group were higher than those in the mild preeclampsia group and the pregnancy hypertension group,and PLT was lower than that in the mild preeclampsia group and the pregnancy hypertension group,and the differences were statistically significant(P<0.05).Conclusion There are coagulation dysfunction and platelet activation in patients with gestational hypertension.Strengthening the monitoring of the coagulation function indexes and platelet parameters can predict the degree of illness of patients with gestational hypertension,so as to ensure the health of mothers and in

关 键 词：妊娠期高血压 凝血功能 血小板 

分 类 号：R714.24[医药卫生—妇产科学]