正常高值血压男性血清chemerin水平与代谢指标的相关性研究  

Relationship between serum chemerin and metabolic parameters in prehypertensive men

作　　者：李靖[1] 刘芙蓉[2] Li Jing;Liu Furong(Department of Endocrinology,Tai'an Second Hospital of Traditional Chinese Medicine,Tai'an 217000,China;The Kidney Disease Clinical Center,the Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001,China)

机构地区：[1]山东省泰安市中医二院内分泌科,217000 [2]山东中医药大学第二附属医院肾病诊疗中心,济南250001

出　　处：《中华临床医师杂志（电子版）》2020年第1期39-42,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨正常高值血压男性患者血清chemerin水平与代谢指标的关系。方法选择健康体检的30~60岁男性198名作为研究对象,根据血压水平分为正常血压组66名、正常高值血压组69名及高血压组63名。比较各组间血清chemerin水平的变化,分析其与血糖、血脂、血压及胰岛素抵抗等代谢指标的相关性。结果3组chemerin水平具有明显差异,正常高值血压组[(41.44±2.28)ng/L]、高血压组[(46.80±6.08)ng/L]血清chemerin水平较正常血压组升高[(33.10±2.47)ng/L],且高血压组显著高于正常高值血压组(P<0.05)。相关分析显示正常高值血压组和高血压组的腰围与chemerin水平的变化呈正相关(正常高值血压组:r=0.275,P=0.022;高血压组:r=0.550,P<0.001),高血压组胰岛素抵抗指数与chemerin水平的变化呈正相关(r=0.457,P<0.001)。结论随血压升高,血清chemerin水平亦显著升高,且与肥胖及胰岛素抵抗密切相关,可能是正常高值血压向高血压进展的重要启动因子之一。Objective To investigate the relationship between serum chemerin levels and metabolic indicators in prehypertensive men.Methods A total of 198 men aged from 30 to 60 who participated in the physical examinations were selected as study subjects.According to the blood pressure,they were divided into three groups:normal group(66),prehypertension group(69)and hypertension group(63).The changes in serum chemerin levels were compared between groups and their correlation with metabolic indicators such as blood sugar,lipids,blood pressure,and insulin resistance were analyzed.Results The levels of chemerin were significantly different among the three groups(P<0.05).Serum chemerin levels in the prehypertension group[(41.44±2.28)ng/L]and hypertension group[(46.80±6.08)ng/L]were higher than that of the normal group[(33.10±2.47)ng/L],and serum chemerin level in the hypertension group was notably higher than that of the prehypertension group.Spearman correlation analysis revealed that the change of waist circumferenc and serum chemerin level in the prehypertension and hypertension groups was positively correlated(prehypertension group:r=0.275,P=0.022;hypertension group:r=0.550,P<0.001),and the insulin resistance index in the hypertension group(r=0.457,P<0.001)correlated positively with the change of serum chemerin level.Conclusion Serum chemerin level notably increases as the blood pressure increases and positively correlates with obesity and insulin resistance,suggesting that serum chemerin may be one of the important initiators in the progression from prehypertension to hypertension.

关 键 词：正常高值血压 血清chemerin 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病]