戊酸雌二醇与屈螺酮炔雌醇片对稽留流产清宫术后子宫内膜修复的效果比较  

Comparison of the effects of estradiol valerate and drospirone ethinylestradiol tablets on endometrial repair after uterine curettage for missed abortion

作　　者：陈春苗 陈艳[1] 阮爱春 CHEN Chunmiao;CHEN Yan;RUAN Aichun(Reproductive Department,Wenchang People′s Hospital,Wenchang 571300,Hainan,China;Gynecology Department,Wenchang People′s Hospital,Wenchang 571300,Hainan,China)

机构地区：[1]文昌市人民医院生殖科,海南文昌571300 [2]文昌市人民医院妇科,海南文昌571300

出　　处：《中国性科学》2020年第4期71-74,共4页Chinese Journal of Human Sexuality

摘　　要：目的探讨戊酸雌二醇与屈螺酮炔雌醇片对稽留流产清宫术后子宫内膜修复的疗效。方法选取2017年6月至2018年12月文昌市人民医院诊治的稽留流产且行清宫术治疗的180例患者作为研究对象。根据患者接受的治疗药物将其分为戊酸雌二醇组和屈螺酮炔雌醇组,每组90例患者。观察两组患者术后的月经复潮时间、月经量、阴道流血时间、术后第14d子宫内膜厚度;统计两组患者术后并发症,如宫腔积液、盆腔炎、宫腔粘连、月经紊乱等情况;同时,记录两组用药过程中的不良反应,如乳房胀痛、头晕、头痛、恶心等情况。结果戊酸雌二醇组患者术后月经量正常率高于屈螺酮炔雌醇组患者,且阴道流血时间短于屈螺酮炔雌醇组,月经复潮时间长于屈螺酮炔雌醇组,子宫内膜厚度指标明显优于屈螺酮炔雌醇组,其差异均具有统计学意义(均P<0.05);戊酸雌二醇组患者术后并发症发生率为6.7%,明显低于屈螺酮炔雌醇组患者(16.7%),其差异具有统计学意义(P<0.05);戊酸雌二醇组患者用药过程中不良反应发生率(7.8%)略低于屈螺酮炔雌醇组(8.9%),其差异无统计学意义(P>0.05)。结论戊酸雌二醇和屈螺酮炔雌醇片均能够有效缩短稽留流产清宫术后阴道流血时间、促进子宫内膜修复,戊酸雌二醇效果更优,更适合稽留流产患者清宫术后使用。Objective To investigate the effect of estradiol valerate and drospirone ethinylestradiol tablets on endometrial repair after uterine curettage for missed abortion. Methods 180 patients with missed abortion that received curettage in Wenchang People′s Hospital from June 2017 to December 2018 were selected as the study subjects. The patients were divided into estradiol valerate group and drospirone ethinylestradiol group according to the drug treatment they received, 90 cases in each group. The time of menstruation, menstrual volume, vaginal bleeding and endometrial thickness on the 14 th day after operation were observed. The complications such as hydrocele, pelvic inflammation, uterine adhesions and menstrual disorders were counted. The adverse reactions such as breast pain, dizziness, headache and nausea were recorded. Results The normal rate of menstrual volume in estradiol valerate group was higher than that in drospirone ethinylestradiol group, the time of vaginal bleeding was shorter than that in drospirone ethinylestradiol group, the recovery time of menstruation was longer than that in drospirone ethinylestradiol group, and the index of endometrial thickness was significantly better than that in drospirone ethinylestradiol group, all with statistically significant differences(all P<0.05). The incidence of complications in estradiol valerate group was 6.7%, lower than that in drospirone ethinylestradiol group of 16.7%, with statistically significant differences(P<0.05). The incidence of adverse reactions in estradiol valerate group(7.8%) was slightly lower than that in drospirone ethinylestradiol group(8.9%), with no statistically significant differences(P>0.05). Conclusions Both drospirenone ethinylestradiol tablets and estradiol valerate can effectively shorten the time of vaginal bleeding after curettage for missed abortion and promote the repair of endometrium. Estradiol valerate has better effect and is more suitable for patients with missed abortion after operation.

关 键 词：稽留流产 清宫术 子宫内膜修复 戊酸雌二醇 屈螺酮炔雌醇片 

分 类 号：R714[医药卫生—妇产科学]