清热补肾排石方对上尿路结石患者PCNL术后残石排出及尿液成分的影响  

Effect of Qingre Bushen Paishi prescription on remnant stone excretion and urine composition in patients with upper urinary calculus after PCNL operation

作　　者：祝秀文[1] 童炎岳[1] 万里军[1] 雷樟铭[1] 朱剑勇[1] ZHU Xiuwen;TONG Yanyue;WAN Lijun;LEI Zhangming;ZHU Jianyong(Department of urinary surgery,People′s hospital of Quzhou,Quzhou 324000,Zhejiang,China)

机构地区：[1]衢州市人民医院泌尿外科,浙江衢州324000

出　　处：《中国性科学》2020年第4期121-124,共4页Chinese Journal of Human Sexuality

摘　　要：目的探究清热补肾排石方对上尿路结石患者经皮肾镜碎石术(PCNL)术后残石排出及尿液成分的影响。方法选取2017年10月至2019年4月在衢州市人民医院诊治的上尿路结石患者83例作为研究对象,按照随机数字表法分为观察组(n=42)和对照组(n=41)。对照组患者采用PCNL进行治疗,观察组在对照组的基础上采用清热补肾排石方进行治疗,比较两组患者的临床总有效率、中医症候积分、结石排净时间、住院时间,24h尿枸橼酸,以及尿草酸、尿钙水平。结果观察组患者的临床总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗后两组患者的中医症候积分明显低于治疗前(P<0.05),且观察组患者的中医症候积分明显低于对照组(P<0.05),差异均具有统计学意义;观察组患者的结石排净时间、住院时间明显少于对照组,差异均具有统计学意义(P<0.05);治疗后两组患者的24h尿枸橼酸水平明显高于治疗前,尿草酸、尿钙水平明显低于治疗前(P<0.05),且观察组患者的24h尿枸橼酸水平明显高于对照组(P<0.05),差异具有统计学意义,但两组患者治疗后的尿草酸、尿钙水平比较差异无统计学意义(P>0.05)。结论清热补肾排石方对上尿路结石患者具有显著的临床疗效,能有效促进残石排出,改善尿液成分。Objective To explore the effect of Qingre Bushen Paishi prescription on residual stone excretion and urine composition in patients with upper urinary tract stones after percutaneous nephrolithotomy(PCNL). Methods A total of 83 patients with upper urinary tract calculi treated in our hospital from Oct. 2017 to Apr. 2019 were selected and divided into observation group(n=42) and control group(n=41) according to random number table method. The patients in the control group were treated with PCNL, while the patients in the observation group were treated with Qingre Bushen Paishi prescription on the basis of the control group. The clinical total effective rate, traditional Chinese medicine symptom score, stone clearance time, hospitalization time, 24-hour urinary citric acid, oxalic acid and urinary calcium levels were compared between the two groups. Results The clinical total effective rate of the observation group was significantly higher than that of the control group, with statistically significant differences(P<0.05). After treatment, the scores of traditional Chinese medicine symptoms in the two groups were significantly lower than those before treatment, and the scores in the observation group were significantly lower than those in the control group, all with statistically significant differences(P<0.05). The stone clearance time and hospitalization time in the observation group were significantly shorter than those in the control group, with statistically significant differences(P<0.05);The 24-hour urinary citric acid level of the two groups after treatment was significantly higher than that before treatment, the levels of uric oxalate and urinary calcium were significantly lower than those before treatment, and the 24-hour urinary citric acid level of the observation group was significantly higher than that of the control group, all with statistically significant differences(all P<0.05), but there was no significant difference in the levels of uric oxalate and urinary calcium between the two groups(P>0.05).

关 键 词：清热补肾排石方 上尿路结石 经皮肾镜碎石术 残石 尿液成分 

分 类 号：R275[医药卫生—中医皮科]