基于p-TsOH促进的芳酮醛水合物与腈的Ritter三组分反应双酰胺衍生物的合成  

Synthesis of diamides via p-TsOH-promoted Ritter three-component reaction of arylglyoxals and nitriles

作　　者：秦雪 何龙 王世达 李佳倬 李庆雪 郝文娟 Qin Xue;He Long;Wang Shida;Li Jiazhuo;Li Qingxue;Hao Wenjuan(School of Chemistry&Materials Science,Jiangsu Normal University,Xuzhou 221116,Jiangsu,China)

机构地区：[1]江苏师范大学化学与材料科学学院,江苏徐州221116

出　　处：《江苏师范大学学报（自然科学版）》2020年第1期61-67,共7页Journal of Jiangsu Normal University：Natural Science Edition

基　　金：Research supported by the National Natural Science Foundation of China(2160208);National innovation and entrepreneurship training program for college students(201810320156X,201810320019Z)。

摘　　要：介绍一类高效p-TsOH促进的Ritter三组分反应.该反应以芳酮醛水合物与各种腈为原料,原子经济地合成了一系列N,N′-烷基双酰胺衍生物,产率优良.该方法具有底物范围广、官能团耐受性好、原子利用率高、反应条件温和等特点.双酰胺产物的纯化只需用水洗涤,避免了传统的柱层析和重结晶,属于基团辅助纯化(GAP)化学.An efficient p-TsOH-promoted Ritter three-component reaction of arylglyoxals and various nitriles was described,providing an atom economical protocol toward N,N′-alkyl diamides with generally good yields.The protocol features the wide scope of substrates,good tolerance of functional groups and high atom utilization as well as mild reaction conditions.The purification of these products only needs to be carried out by washing with water,thereby avoiding traditional chromatography and recrystallization,which belongs to group-assisted purification(GAP)chemistry.

关 键 词：Ritter反应 三组分反应 N N′-烷基双酰胺衍生物 水合反应 原子经济 

分 类 号：O626.4[理学—有机化学]