microRNA调控胆固醇代谢研究进展  

MicroRNA Regulates Cholesterol Metabolism:a Review

作　　者：胡亚军[1] 胡毅[1] HU Yajun;HU Yi(Hunan Engineering Technology Research Center of Featured Aquatic Resources Utilization,Hunan Agricultural University,Changsha 410128,China)

机构地区：[1]湖南农业大学,湖南特色水产资源利用工程技术研究中心,长沙410128

出　　处：《动物营养学报》2020年第5期1965-1972,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金面上项目(31572626)。

摘　　要：microRNA(miRNA)是一种非编码蛋白的短序列RNA,通过与靶基因靶标区的序列互补配对,抑制mRNA翻译或直接降解mRNA,对靶基因表达起负调控作用。胆固醇是合成机体生理活性物质的重要原料,也是构成细胞膜的主要成分。近年来,关于miRNA调控胆固醇代谢相关研究被重视和报导。本文就miRNA对动物胆固醇代谢调控相关研究进行综述。MicroRNA(miRNA)is a kind of short sequence RNA that does not encode protein.It plays a neg ative role for the target mRNA expression by pairing with complementary sequence of the target gene,and in hibits the transcription of mRNA,even degrades mRNA.Cholesterol is not only an important raw material for the synthesis of physiological active substances,but also the main component of cell membrane.Recent years,there are mounts of papers about the regulation of cholesterol metabolism by miRNA,this review focused on the regulation of animal cholesterol metabolism by miRNA.

关 键 词：MICRORNA MRNA 胆固醇代谢 

分 类 号：S811[农业科学—畜牧学]