冠心苏合丸配合PCI治疗急性心肌梗死的疗效观察及对心功能、氧化应激指标水平的影响  

The Effeet of Guanxin Suhe Pill and PCI on Cardiac Function and Oxidative Stress Indicators Levels

作　　者：邹燕[1] 李理[1] 邹亚芳 ZOU Yan;LI Li;ZOU Yafang(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学附属医院,沈阳110032

出　　处：《中西医结合心脑血管病杂志》2020年第7期1106-1109,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探究冠心苏合丸配合经皮冠状动脉介入术(PCI)治疗急性心肌梗死的临床疗效,并观察对病人氧化应激指标、心功能水平的影响。方法收集于我院治疗的急性心肌梗死病人110例,通过随机数字表法分为对照组(55例,予以PCI手术治疗)与观察组(55例,在对照组治疗基础上,PCI术第3天后予以冠心苏合丸口服,治疗时间4周)。两组治疗后比较肌钙蛋白I(cTnI)、心功能水平变化情况,检测两组血清丙二醛(MDA)、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)表达水平变化情况。结果经4周治疗后,观察组左室舒张末期内径(LVEDD)、左室射血分数(LVEF)改善水平均优于对照组(P<0.05)。观察组治疗2周及4周后血清cTnI水平均较对照组降低(P<0.05)。观察组心脏不良事件发生率(16.36%)明显低于对照组(32.72%,P<0.05)。治疗后,观察组血清SOD、GSH升高水平及MDA降低水平优于对照组,差异有统计学意义(P<0.05)。结论冠心苏合丸配合PCI治疗急性心肌梗死可显著提高临床疗效,改善心功能,并且可以有效缓解病人过度的氧化应激水平。Objective To explore the clinical efficacy of Guanxin Suhe pill(GSP)and percutaneous coronary intervention(PCI)on oxidative stress index and cardiac function in treatment of AMI.Methods A total of 110 patients with AMI treated were divided into control group(n=55)and observation group(n=55)by random number table.The patients in control group were treated with PCI.The patients in observation group were treated with GSP after 3 days of PCI for 4 weeks.After treatment,the troponin I(cTnI)and cardiac function were compared between the two groups.The levels of serum malondialdehyde(MDA),superoxide dismutase(SOD)and reduced glutathione(GSH)were detected.Results After 4 weeks of treatment,the left ventricular end-diastolic diameter and left ventricular ejection fraction(LVEF)in the observation group were better than those in the control group(P<0.05).The level of serum cTnI in the observation group was significantly lower than that in the control group after 2 and 4 weeks of treatment(P<0.05).At the same time,the incidence of adverse cardiac events in the observation group was significantly lower than that in the control group(16.36%vs 32.72%,P<0.05).After treatment,the levels of serum SOD,GSH and MDA in the observation group were significantly higher than those in the control group(P<0.05).Conclusion GSP and PCI can significantly improve the clinical efficacy of AMI,improve the cardiac function,and effectively alleviate the excessive oxidative stress level in patients.

关 键 词：急性心肌梗死 冠心苏合丸 肌钙蛋白I 还原型谷胱甘肽 超氧化物歧化酶 丙二醛 

分 类 号：R542.2[医药卫生—心血管疾病] R256.2[医药卫生—内科学]