母-胎界面T细胞功能研究进展  

Research advances in the function of T cells at the maternal-fetal interface

作　　者：黄茜茜 刘璐[1,3] 王莉 杜美蓉[1,2,3] HUANG Xi-Xi;LIU Lu;WANG Li;DU Mei-Rong(Institute of Obstetrics and Gynecology,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China;Key Laboratory of Reproduction Regulation of the National Population and Family Planning Commission(NPFPC),Shanghai 200032,China;Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai 200011,China;Department of Integrated Traditional and Western Medicine,Hospital of Obstetrics and Gynecology,Fudan University,Shanghai 200011,China)

机构地区：[1]复旦大学附属妇产科医院研究所,上海200011 [2]国家人口和计划生育委员会计划生育药具重点实验室,上海200032 [3]上海市女性内分泌相关疾病重点实验室,上海200011 [4]复旦大学附属妇产科医院中西医结合科,上海200011

出　　处：《生理学报》2020年第1期11-19,共9页Acta Physiologica Sinica

摘　　要：母-胎界面免疫耐受是成功妊娠建立和维持的基础,T细胞是子宫蜕膜免疫细胞的重要组成细胞,既要介导抗感染免疫,保护胚胎免遭外来病原体攻击,同时又要参与母体接受同种异体胚胎的复杂免疫调节过程,在调控胚胎植入和维持妊娠过程中发挥重要作用,其功能失调可能会导致早期妊娠失败或中晚期妊娠并发症。本文就近年来关于妊娠期母-胎界面T细胞亚群的组成、表型特征及其功能进行介绍,并进一步阐述蜕膜CD4^+与CD8^+T细胞在母-胎免疫调节中的作用,以及异常调控致早期妊娠失败的分子机制,有助于深入理解母-胎免疫耐受机制,为妊娠相关疾病的防治提供新的线索。Immune tolerance at maternal-fetal interface is the basis for establishment and maintenance of successful pregnancy. T cells are pivotal compositions of uterine decidual immune cells, which are required to mediate anti-infection immunity and protect embryos from external antigens attack. T cells also participate in the complex immune regulation process of maternal acceptance of semi-allogeneic embryos, and play an important role in regulating embryo implantation and maintaining pregnancy. Its dysfunction may lead to early pregnancy failures or mid-late pregnancy complications. This review summarizes the compositions, phenotypic characteristics and functions of decidual T cells at the maternal-fetal interface in recent years, and further describes the regulation of decidual CD4^+ and CD8^+ T cells in maternal-fetal immune tolerance as well as the molecular mechanisms of abnormal regulation leading to early pregnancy failures. Through the in-depth understanding the mechanism of maternal-fetal immune regulation, it supplies a novel concept on maternal-fetal immune tolerance and new clues for the immunotherapy of pregnancy-related diseases.

关 键 词：T细胞 母-胎界面 母-胎免疫耐受 妊娠相关疾病 

分 类 号：R392.1[医药卫生—免疫学] R711.6[医药卫生—基础医学]