Effect and mechanism study on transcutaneous auricular vagus nerve stimulation for functional dyspepsia model rats  

经皮耳迷走神经刺激干预功能性消化不良模型大鼠的效应及机制研究

作　　者：Li-wei HOU Pei-jing RNG Wei WEI Ji-liang FANG Dan WANG Wei-hang ZHAI Yu WANG Jun-ying WANG 侯理伟;荣培晶;魏玮;方继良;王丹;翟伟航;王瑜;王俊英(中国中医科学院针灸研究所,北京100700;中国中医科学院望京医院,北京100102;中国中医科学院广安门医院,北京100053;湖北中医药大学,武汉430061;华北理工大学,河北唐山063210)

机构地区：[1]China Academy of Chinese Medical Sciences,Institute of Acupuncture and Moxibustion,Beijing 100700,China [2]Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China [3]Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China [4]Hubei University of Chinese Medicine,Wuhan 430061,China [5]North China University of Science and Technology,Tangshan 063210,Hebei,China

出　　处：《World Journal of Acupuncture-Moxibustion》2020年第1期49-56,共8页世界针灸杂志（英文版）

基　　金：Supported by International Cooperation and Exchange of the National Natural Science Foundation of China:NO.81820108033;81473780;The Fundamental Research Funds for the Central public welfare research institutes:NO.ZZ201915009.

摘　　要：Objective:To explore the effect and its possible mechanism of the intervention of transcutaneous auricular vagus nerve stimulation(taVNS)for the functional dyspepsia(FD)model rats.Methods:Of the 25 male SD rats,6 rats were set as blank group,the other 19 rats were established to be the functional dyspepsia(FD)model by iodoacetamide intragastric administration,and 18 FD models were successfully established.The 18 model rats were randomly divided into a model group,a shamtaVNS group,and taVNS group,with 6 rats in each group.There was no intervention applied to the rats in the blank and model groups.Whereas,the rats in sham-taVNS group received stimulation to the rim of auricular concha of both sides,and those in taVNS group received stimulation to the cavity of auricular concha of both sides,for 30 min each time,once a day,7 days in succession.After the intervention,the gastric sensitivity of the rats in each group under different pressure conditions in the stomach,the expressions of serum brain-gut peptide motilin(MTL),cholecystokinin(CCK),glucagon-likepeptidel(GLP-1),and inflammatory factors IL-4,IL-10,and IL-1βwere detected.Results:(1)Gastric sensitivity:compared with the blank group,the gastric sensitivity of the model group was higher(P<0.05).Compared with the model group,the gastric sensitivity of the taVNS group was lower(P<0.05).Compared with the sham-taVNS group,the gastric sensitivity of the taVNS group was lower(P<0.05).(2)Expression of brain-gut peptide:compared with the blank group,MTL was lower,CCK and GLP-1 were higher in the model group(all P<0.05).Compared with the model group,MTL was higher,CCK and GLP-1 were lower in the taVNS group(all P<0.05).Compared with the shamtaVNS group,CCK and GLP-1 were lower in the taVNS group(both P<0.05).(3)Expression of inflammatory factors:compared with the blank group,IL-4 and IL-10 were lower and was higher in the model group(all P<0.05).Compared with the model group,IL-10 was higher and IL-1βwas lower in the shamtaVNS group(all P<0.05),while IL-4 and IL-10 wer

关 键 词：TRANSCUTANEOUS AURICULAR VAGUS NERVE stimulation(taVNS) Functional dyspepsia(FD) VAGUS NERVE Inflammatory factor Brain-gut peptide 

分 类 号：R245[医药卫生—针灸推拿学]