2017年太原市手足口病流行特征及病原学分析  

Epidemiology and pathogenic analysis of hand,foot and mouth disease in Taiyuan,2017

作　　者：高瑞红[1] 韩瑞 左芝红[1] 王骥涛[1] Gao Ruihong;Han Rui;Zuo Zhihong;Wang Jitao(Department of Microbiological Laboratory,Taiyuan Center for Disease Control and Prevention,Shanxi 030012,China)

机构地区：[1]太原市疾病预防控制中心微生物检验科,030012

出　　处：《中国药物与临床》2020年第9期1428-1431,共4页Chinese Remedies & Clinics

基　　金：山西省卫生厅科学技术攻关项目(201302026)。

摘　　要：目的分析2017年太原市手足口病流行特征及病原型别,为太原市手足口病防治提供科学依据。方法从中国疾病预防控制信息系统获取2017年太原市手足口病资料,通过Excel和SPSS 22.0进行流行病学分析;采用荧光定量逆转录-聚合酶链反应对太原市疾病预防控制中心2017年收集的583份手足口病病例标本进行核酸检测。结果2017年太原市手足口病发病6494例,年发病率为149.48/10万;男女比例为1.37∶1;发病年龄以5岁及5岁以下儿童多见,占89.34%;发病率最高是阳曲县,达322.4/10万。发病高峰在6-8月,11月出现了次高峰。对583例手足口病样本进行核酸检测,阳性标本285例,阳性率为48.89%,主要型别为CVA6、EV71和CVA16,分别占比50.18%、22.11%和17.19%。结论太原市手足口病的分布呈现出人群差异、季节差异、地区差异,病毒型别以CVA6型占比最大。Objective To charaterizethe epidemiology and pathogens of hand,foot and mouth disease(HFMD)in Taiyuan,2017,and to provide evidence for the prevention and treatment.Methods The data on HFMD in Taiyuan,2017,were obtained from the Chinese Disease Prevention and Control Information System.Epidemiological analysis was performed with Excel and SPSS 22.0.The samples from 583 HFMD patients collected by Taiyuan Municipal Center for Disease Control and Prevention in 2017 were examined with fluorescent quantitative reverse transcriptionpolymerase chain(RT-PCR)for detection of viral nucleic acid.Results The HFMD affected 6494 people in Taiyuan,2017,accounting for an annual incidence rate of 149.48/100000;the ratio of male to female was 1.37∶1,and the onset was more common in children aged 5 and under,accounting for 89.34%of the total.The Yangqu County was mostseverely hit with an incidence rate of 322.4/100000.The incidence presented a higherpeak during June to August and a second,smaller peak in November.Nucleic acid detection was performed on 583 samples from HFMD patients,with positive findings in 285 sample and ayield of 48.89%.The predominant pathogens were CVA6(50.18%),EV71(22.1%)and CVA16(17.19%),respectively.Conclusion The distribution of hand,foot and mouth disease in Taiyuan shows variety according to population subgroup,seasonality and geography.CVA6 is the predominant pathogen type of HFMD.

关 键 词：手足口病 肠道病毒 病原学 流行特征 

分 类 号：R725.1[医药卫生—儿科] R181.3[医药卫生—临床医学]