1例高血压伴低血钾患者降压药物对醛固酮肾素活性比值的影响分析及应对策略  

Effect Analysis and Countermeasures for Antihypertensive Drugs on Aldosterone Renin Ratio of a Patient with Hypertension and Hypokalemia

作　　者：马红妹 常德玉 侯幸赟[1] 陶霞[1] 陈万生[1] Ma Hongmei;Chang Deyu;Hou Xingyun;Tao Xia;Chen Wansheng(Department of Pharmacy,Changzheng Hospital,Shanghai 200003,China;Department of Pharmacy,People1's Hospital of Rizhao)

机构地区：[1]上海长征医院药学部,上海200003 [2]山东省日照市人民医院药学部

出　　处：《中国药师》2020年第4期680-681,共2页China Pharmacist

基　　金：上海市卫生计生系统重要薄弱学科建设计划资助项目(编号:2016ZB0303)。

摘　　要：高血压伴持续性低血钾或难治性高血压应筛查原发性醛固酮增多症,常将醛固酮肾素活性比值作为筛查指标,本文通过临床药师参与1例高血压伴低血钾患者的降压方案调整,测定血浆醛固酮和肾素活性水平的比值(ARR),分析不同类型降压药物对ARR的影响,并对降压用药方案进行调整。阐述了临床药师深入临床,通过监测药物不良反应及临床疗效进行药学监护,有助于提高药学服务质量,促进药物合理使用。Persistent hypokalemia or refractory hypertension should perform primary aldosteronism screening with the aldosterone renin activity ratio as the screening index. Clinical pharmacists participated in the antihypertensive scheme adjustment for a patient with hypertension associated with hypokalemia by determining the level of plasma aldosterone and renin activity ratio( ARR),analyzing the influence of the different types of antihypertensive drugs on ARR and adjusting the scheme of antihypertensive drugs. The paper expounded that clinical pharmacists can monitor the adverse drug reactions and clinical efficacy deeply in clinical practice and carry out pharmaceutical care,which is helpful to improving the quality of pharmaceutical care and promoting the rational drug use.

关 键 词：降压药 醛固酮肾素活性比值 应对策略 药学监护 

分 类 号：R97[医药卫生—药品]