注射用复合辅酶联合曲美他嗪治疗心绞痛的临床效果  

Clinical effects of coenzyme complex for injection combined with trimetazidine in the treatment of angina pectoris

作　　者：杨瑜珍 郑凯特 陈冰 曾斯璐 陆海玲 YANG Yuzhen;ZHENG Kaite;CHEN Bing;ZENG Silu;LU Hailing(Clinical Pharmacy Room,Department of Pharmacy,First TCM Hospital of Zhanjiang,Guangdong,Zhanjiang 524043,Chin)

机构地区：[1]广东省湛江市第一中医医院药学部临床药学室,广东湛江524043

出　　处：《中国医药科学》2020年第7期78-81,共4页China Medicine And Pharmacy

摘　　要：目的探讨注射用复合辅酶联合曲美他嗪治疗心绞痛的临床效果。方法选择2018年1月~2019年1月在我院接受治疗的68例心绞痛患者进行研究。按照随机数字表法将其分为对照组(n=34)和研究组(n=34)。对照组患者使用曲美他嗪进行治疗,研究组使用注射用复合辅酶联合曲美他嗪进行治疗。比较两组患者治疗前后的临床症状、血液流变学、西雅图心绞痛量表评分,并统计两组治疗有效率。结果治疗后,两组的心绞痛发作频率低于治疗前,疼痛延续时间短于治疗前,差异有统计学意义(P<0.05),且研究组的心绞痛发作频率低于对照组,疼痛延续时间短于对照组,差异有统计学意义(P<0.05)。两组的血浆黏度和血细胞比容(HCT)低于治疗前(P<0.05),研究组的血浆黏度和HCT低于对照组,差异有统计学意义(P<0.05)。两组的心绞痛发作情况、心绞痛稳定状态、躯体活动受限情况、治疗满意度以及疾病认识程度的评分高于治疗前,差异有统计学意义(P<0.05),且研究组的心绞痛发作情况、心绞痛稳定状态、躯体活动受限情况、治疗满意度以及疾病认识程度的评分高于对照组,差异有统计学意义(P<0.05)。研究组的治疗总有效率为85.3%,明显高于对照组的67.6%,差异具有统计学意义(P<0.05)。结论与单纯使用曲美他嗪比较,注射用复合辅酶与曲美他嗪联用对心绞痛具有较好的效果,可以有效降低心绞痛发作频率,缩短疼痛时间,改善患者的血液动力学,具有较高的心绞痛量表评分,在临床上值得广泛使用。Objective To investigate the clinical effects of coenzyme complex for injection combined with trimetazidine in the treatment of angina pectoris.Methods 68 patients with angina pectoris who were treated at our hospital from January 2018 to January 2019 were selected for the study.They were divided into the control group(n=34)and the study group(n=34)according to the random number table method.Patients in the control group were treated with trimetazidine,while patients in the study group were treated with coenzyme complex for injection combined with trimetazidine.The clinical symptoms,hemorheology,and Seattle angina questionnaire(SAQ)score of the two groups of patients before and after treatment were compared,and the response rate of the two groups was calculated.Results After treatment,the frequency of angina pectoris attack in the two groups was lower than that before treatment,and the pain duration was shorter than that before treatment,with statistically significant difference(P<0.05);Moreover,the frequency of angina pectoris attack in the study group was lower than that in the control group,and the pain duration was shorter than that in the control group,with statistically significant difference(P<0.05).The plasma viscosity and hematocrit(HCT)in the two groups were lower than those before treatment(P<0.05);And the plasma viscosity and HCT in the study group were lower than those in the control group,with statistically significant difference(P<0.05).The scores of angina pectoris attack,stable state of angina pectoris,limited physical activity,treatment satisfaction,and disease awareness in the two groups were higher than those before treatment,with statistically significant difference(P<0.05);Moreover,the scores of angina pectoris attack,stable state of angina pectoris,limited physical activity,treatment satisfaction,and disease awareness in the study group were higher than those in the control group,with statistically significant difference(P<0.05).The overall response rate in the study group was 85.3%,which w

关 键 词：注射用复合辅酶 曲美他嗪 心绞痛 血液流变学 

分 类 号：R542.2[医药卫生—心血管疾病]