拮抗剂方案和激动剂方案在多囊卵巢综合征患者中的卵泡输出率对比  

Comparison of follicle output rate between antagonist and agonist regimens in patients with polycystic ovary syndrome

作　　者：王梦[1] 郭沛沛[1] 张乐 项云改[1] 张丹[1] 谭丽[1] Wang Meng;Guo Peipei;Zhang Le;Xiang Yungai;Zhang Dan;Tan Li(Department of Reproductive Medicine,the Second Affiliated Hospital of Zhengzhou University,Henan 450000,China)

机构地区：[1]郑州大学第二附属医院生殖医学部,450000

出　　处：《山西医药杂志》2020年第9期1077-1079,共3页Shanxi Medical Journal

摘　　要：目的对比激动剂方案和拮抗剂方案在多囊卵巢综合征患者中的卵泡输出率。方法回顾性选取2018年11月至2019年11月我院多囊卵巢综合征患者100例,依据治疗方法分为拮抗剂方案组(50例)和激动剂方案组(50例)2组,统计分析2组患者的促性腺激素(Gn)用药时间、用量、排卵期前卵泡数(PFC)、获卵数、血清黄体生成素(LH)、雌二醇(E2)水平、内膜厚度、周期取消率、受精率、卵裂率、优胚率、卵泡输出率、妊娠结局。结果拮抗剂方案组患者的Gn用药时间显著短于激动剂方案组(P<0.05),Gn用量显著少于激动剂方案组(P<0.05),血清LH水平显著高于激动剂方案组(P<0.05),血清雌二醇水平显著低于激动剂方案组(P<0.05),周期取消率显著低于激动剂方案组(P<0.05),但2组患者的PFC、获卵数、内膜厚度、受精率、卵裂率、优胚率、卵泡输出率、胚胎种植率、临床妊娠率之间的差异均无统计学意义(P>0.05)。结论激动剂方案和拮抗剂方案在多囊卵巢综合征患者中的卵泡输出率相当。Objective To compare the follicle output rate of agonist and antagonist regimens in patients with polycystic ovary syndrome(PCOS).Methods One hurdred cases of patients with PCOS in our hospital from November 2018 to November 2019 were selected retrospectively.According to the treatment methods,they were divided into two groups:antagonistic group(n=50)and agonist group(n=50).The time,dosage of Gn,PFC,numbers of oocytes obtained,serum LH,E2 levels,intimal thickness,cycle cancellation rates,fertilization rates,cleavage rates,excellent embryo rates,follicular output rates and pregnancy outcomes of the two groups were statistically analyzed.Results The administration time of Gn of the antagonistic group was significantly shorter than that of the agonist group(P<0.05),the dosage of Gn was significantly lower than that of the agonist group(P<0.05),the serum LH level was significantly higher than that of the agonist group(P<0.05),the serum E2 level was significantly lower than that of the agonist group(P<0.05),the cycle cancellation rate was significantly lower than that of the agonist group(P<0.05),but the differences of PFC,oocyte numbers,endometrial thickness,fertilization rates,cleavage rates,excellent embryo rates,follicle output rates,embryo implantation rates and clinical pregnancy rates between the two groups were not significant(P>0.05).Conclusion The follicle output rates of agonist regimen and antagonist regimen in patients with PCOS are similar.

关 键 词：多囊卵巢综合征 激动剂方案 拮抗剂方案 卵泡输出率 

分 类 号：R711.75[医药卫生—妇产科学]