基于晶格玻尔兹曼方法研究不同出口压力条件下淋巴管内氮含量的变化及影响  

Investigation of NO content varaitaion in the lymphatic vessels under different outlet pressures by a lattice Boltzmann method

作　　者：赫轶男 张乾毅 韦华建 施娟 He Yi-Nan;Zhang Qian-Yi;Wei Hua-Jian;Shi Juan(School of Material Science and Engineering,Guilin University of Electronic Technology,Guilin 541004,China;School of Information and Communication,Guilin University of Electronic Technology,Guilin 541004,China)

机构地区：[1]桂林电子科技大学材料科学与工程学院,桂林541004 [2]桂林电子科技大学信息与通讯学院,桂林541004

出　　处：《物理学报》2020年第10期18-25,共8页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:11362005)资助的课题.

摘　　要：淋巴系统是人体内重要的防御功能系统,具有三大免疫功能,首先是能够抵御细菌病毒,使人体免于疾病的攻击;其次是由淋巴细胞加以辅助,清除由新陈代谢而出的产物;最后是由淋巴细胞来修补受损的器官与组织,使其恢复正常的生理功能。淋巴系统没有像血液循环系统中心脏一样的动力泵,淋巴液的驱动主要靠淋巴管的自主收缩来完成(肺淋巴系统是靠肺泡的运动)。淋巴管的自主收缩循环是由淋巴肌细胞内钙离子增加产生收缩,收缩驱动流体产生剪切力,剪切力使淋巴内皮细胞产生一氧化氮合酶(eNOS),一氧化氮合酶使一氧化氮增加,一氧化氮的增加降低钙离子使淋巴管松弛,淋巴管松弛后流体剪切率下降,eNOS下降,一氧化氮下降,钙离子增加,淋巴肌细胞收缩,开始新的周期。可见一氧化氮的浓度及其分布对淋巴管的收缩起关键作用。显然出口压力会影响淋巴管内流体的剪切率,进而影响一氧化氮的浓度和淋巴管的收缩。为了研究淋巴管出口压力对淋巴管收缩的影响,建立了一个晶格玻尔兹曼模型,模拟嵌入多孔组织的初始淋巴管和有两对瓣膜的集合淋巴管,该模型可以重现一氧化氮、钙的相互影响以及淋巴管的自主收缩,并研究不同出口压力下一氧化氮的分布及其平均值.The lymphatic system is an important defense function system in the human body.It is also critical to humoral homeostasis.Local dysfunction will cause edema,immune deficiency,and a high incidence.There are intraluminal valves in the lymphatic system,which allows the lymph fluid to flow to the large veins and heart.It has three major immune functions.First,it can resist bacterial viruses and protect the human body from disease attacks.Secondly,it is supplemented by lymphocytes to remove the products produced by metabolism.In the end,The damaged organs and tissues are repaired by lymphocytes to restore normal physiological functions.The lymphatic system does not have the same pump as the heart of the blood circulatory system.The driving of lymph is mainly done by the spontaneous contraction of the lymphatics(the lung lymphatic system is compressed by the alveoli).The autonomic contraction cycle of lymphatic vessels is caused by the increase of Ca2+in lymphocytes,and the contraction drives the fluid to produce shearing force.The shearing force produces nitric oxide synthase(eNOS) in lymphatic endothelial cells,and eNOS increases NO and increases NO.Decreasing Ca2+ relaxes lymphatic vessels,fluid shear rate decreases after lymphatic vessel relaxation,eNOS decreases,NO decreases,Ca2+ increases,lymphocytes contract,and a new cycle begins.It can be seen that the concentration of NO and its distribution play a key role in the contraction of lymphatic vessels.Obviously,export pressure affects the shear rate of fluid in the lymphatics,which in turn affects the concentration of NO and the contraction of lymphatic vessels.To investigate the effect of lymphatic outlet pressure on lymphatic vessel contraction,we established a lattice Boltzmann model to simulate the initial lymphatic vessels embedded in porous tissue and the collecting lymphatic vessels with two pairs of valves.The valve is the main source of NO.Once contraction begins,the contraction is spontaneous,self-sustaining,and the system exhibits non-linear dynamics.Th

关 键 词：淋巴管 晶格玻尔兹曼方法 瓣膜 一氧化氮 

分 类 号：R446.1[医药卫生—诊断学]