应用Sonoclot评价急诊PCI术血栓抽吸导管联合替罗非班的临床疗效  

Evaluation of Emergency PCI of Clinical Efficacy of Thrombus Aspiration Catheter Combined with Tirofiban with Sonoclot Analysis

作　　者：宋志宙[1] 高月荣 孟泽军 张萍[1] SONG Zhi-zhou;Gao Yue-rong;Meng Ze-jun;Zhang Ping(Department of Cardiology,The Third People's Hospital of Datong,Datong Shanxi,037008)

机构地区：[1]大同市第三人民医院心血管内科,山西大同037008

出　　处：《山西大同大学学报（自然科学版）》2020年第2期49-51,66,共4页Journal of Shanxi Datong University(Natural Science Edition)

基　　金：大同市科技攻关项目[2016086]。

摘　　要：目的观察急性ST段抬高型心肌梗死(STEMI)急诊冠状动脉介入术(PCI)中应用Sonoclot评价血栓抽吸导管联合替罗非班的临床疗效。方法选取首发急性STEMI患者60例,随机分为对照组(血栓抽吸+球囊扩张后支架植入)及实验组(血检抽吸+球囊扩张后支架植入联合替罗非班)各30例。结果①同组术后8、24h所测ACT、CR、PF与术前相比差异有统计学意义;②2组ACT在术后8及24 h均明显上升,同组间术后8、24 h与术前相比较差异有显著意义;③2组间CR在术后8、24 h同一时间段比较差异有显著意义;④与同组术前相比,2组PF在8、24 h均明显下降,且与同组术前相比差异显著;同组间24 h较8 h相比有下降趋势,且二者相比差异显著。结论应用Sonoclot评价急诊PCI术前、术后凝血及血小板功能简便易行,可指导临床用药;血栓抽吸导管联合替罗非班治疗对血栓负荷重的STEMI患者安全有效,值得推广。Objective To observe the application of Sonoclot to evaluate the clinical efficacy of thrombus aspiration catheter com⁃bined with tirofiban in acute ST segment elevation myocardial infarction(STEMI)emergency coronary intervention(PCI).Methods Six⁃ty patients with first acute STEMI were selected and randomly divided into control group and experimental group after coronary angiog⁃raphy.Results①The ACT,CR,and PF measured at 8 and 24 hours after surgery in the same group were significantly different from those before surgery.②The ACT in both groups increased significantly at 8 and 24 hours after surgery,and the difference between 8 and 24 hours after surgery in the same group was significantly different from that before surgery.③The difference between CR be⁃tween the two groups at the same time period 8h and 24h after surgery was significant.④Compared with the same group before sur⁃gery,PF decreased significantly at 8 h and 24 h,and the difference was significantly different from that of the same group before sur⁃gery;There was a downward trend between 24 h and 8 h in the same group,and the difference was significant.Conclusion The use of Sonoclot to evaluate coagulation and platelet function before and after emergency PCI is simple and easy to guide clinical medication.The thrombus aspiration catheter combined with tirofiban is safe and effective for patients with STEMI with heavy thrombus,which is worthy of promotion.

关 键 词：SONOCLOT 急性心肌梗死 介入治疗 血栓抽吸 替罗非班 

分 类 号：R543.31[医药卫生—心血管疾病]