择期宫颈环扎术联合间苯三酚治疗宫颈机能不全对孕妇妊娠结局和新生儿的影响  

Effect of selective cervical cerclage combined with Phloroglucinol on pregnancy outcome and newborn of pregnant women with cervical insufficiency

作　　者：吴国荧 鲁顺琼[1] 王斌[1] WU Guo-ying;LU Shun-qiong;WANG Bin(Department of Obstetrics and Gynecology,Zhaoqing First People′s Hospital in Guangdong Province,Zhaoqing 526000,China)

机构地区：[1]广东省肇庆市第一人民医院妇产科,广东肇庆526000

出　　处：《中国当代医药》2020年第12期119-121,共3页China Modern Medicine

摘　　要：目的探讨择期宫颈环扎术联合间苯三酚治疗宫颈机能不全(CIC)对孕妇妊娠结局和新生儿的影响。方法选取2015年1月~2018年6月我科收治的45例CIC孕妇作为研究对象,根据随机数字表法分为对照组(22例)与观察组(23例)。对照组采用期待疗法,观察组采用择期宫颈环扎术联合间苯三酚,两组孕妇均随访至妊娠结束。比较两组的新生儿预后、妊娠结局。将观察组孕妇根据手术时期分为A组(孕12~16周手术,13例)与B组(孕>16~24周手术,10例),比较两组的新生儿预后及妊娠结局。结果观察组新生儿存活率、出生体重、出生5 min Apgar评分高于对照组,新生儿窒息率低于对照组,差异有统计学意义(P<0.05);观察组分娩孕龄、足月产率高于对照组,流产率、早产率低于对照组,差异有统计学意义(P<0.05);A组足月产率高于B组,早产率低于B组,差异有统计学意义(P<0.05)。结论择期宫颈环扎术联合间苯三酚治疗CIC患者可延长孕龄,有效地改善新生儿预后及妊娠结局,孕早期手术疗效更好。Objective To investigate the effect of selective cervical cerclage combined with Phloroglucinol on pregnancy outcome and neonatal outcome of pregnant women with cervical insufficiency(CIC).Methods A total of 45 pregnant women with CIC admitted to our department from January 2015 to June 2018 were selected as the subjects,and divided into control group(n=22)and observation group(n=23)by random number table method.The control group used expectant therapy,and the observation group were given selective cervical cerclage combined with Phloroglucinol,the two groups were all followed up until the end of pregnancy.The neonatal prognosis and pregnancy outcomes were compared between the two groups.According to the period of operation,the pregnant women of observation group were divided into group A(12-16 weeks of gestation,13 cases)and group B(more than 16 to 24 weeks of gestation,10 cases).The neonatal prognosis and pregnancy outcomes were compared between the two groups.Results The neonatal survival rate,birth weight and 5 min Apgar score in the observation group were higher than those in the control group,and the asphyxia rate was lower than that in the control group,the differences were statistically significant(P<0.05).The gestational week and full-term rate of delivery in the observation group were higher than those in the control group,and the abortion rate and premature delivery rate were lower than those in the control group,the differences were statistically significant(P<0.05).The full-term rate of group A was higher than that of group B,while the premature rate was lower than that of group B,the differences were statistically significant(P<0.05).Conclusion Selective cervical cerclage combined with Phloroglucinol can prolong the gestational age of CIC patients,effectively improve the prognosis and pregnancy outcomes of neonates,and the effect of early pregnancy surgery is better.

关 键 词：宫颈环扎术 间苯三酚 宫颈机能不全 新生儿预后 妊娠结局 

分 类 号：R714.21[医药卫生—妇产科学]