肥胖对OSAHS患者日间嗜睡的影响  

Effect of Obesity on Daytime Sleepiness in Patients with OSAHS

作　　者：郑艳文[1] 邬海燕[1] 胡立红[1] 姜贻乾[1] ZHENG Yanwen;WU Haiyan;HU Lihong;JIANG Yiqian(The First People's Hospital of Xiaoshan District,Hangzhou,Hangzhou 311200,China)

机构地区：[1]杭州市萧山区第一人民医院,浙江杭州311200

出　　处：《中外医学研究》2020年第11期6-8,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：杭州市科技计划引导项目(项目编号:20171226Y90);杭州市科技计划项目(项目编号:20171226Y82)。

摘　　要：目的:探讨肥胖与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者日间嗜睡关系及对OSAHS患者影响。方法:经多导睡眠图(PSG)及体重指数(BMI)测评,分为OSAHS伴肥胖组40例,OSAHS不伴肥胖组38例,单纯肥胖组42例,测定三组体重指数(BMI)、呼吸暂停低通气指数(AHI)、夜间最低血氧饱和度、爱泼沃斯嗜睡量表(ESS)评分、血清瘦素(LEP)水平并进行对比,分析ESS评分与AHI及LEP水平相关性。结果:OSAHS伴肥胖组ESS评分、LEP水平均高于OSAHS不伴肥胖组及单纯肥胖组,差异均有统计学意义(P<0.05);OSAHS不伴肥胖组ESS评分高于单纯肥胖组,差异有统计学意义(P<0.05);OSAHS伴肥胖组ESS评分与LEP水平呈明显正相关性,差异有统计学意义(P<0.05)。结论:OSAHS伴肥胖患者日间嗜睡症状与肥胖有关,而日间嗜睡发病机制可能与LEP水平变化有关。Objective:To investigate the relationship between obesity and daytime sleepiness in patients with OSAHS and its effects on patients with OSAHS.Method:After polysomnography (PSG) and body mass index (BMI) evaluation,40 cases in the OSAHS with obesity group,38 cases in the OSAHS without obesity group,and 42 cases in the simple obesity group.Body mass indexes (BMI),apnea hypopnea indexes (AHI),nighttime minimum oxygen saturation,Epworth sleepiness scale (ESS) scores and serum leptin (LEP) levels were measured and compared among the three groups,and the correlation between ESS score and AHI and LEP levels was analyzed.Result:The ESS score and LEP level of the OSAHS with obesity group were higher than those of the OSAHS without obesity group and the simple obesity group,and the differences were statistically significant (P<0.05).The ESS score of the OSAHS without obesity group was higher than that of the simple obesity group,and the difference was statistically significant (P<0.05).There was a significant positive correlation between ESS score and LEP level in the OSAHS with obesity group,and the difference was statistically significant (P<0.05).Conclusion:The symptoms of daytime sleepiness in patients with OSAHS and obesity are related to obesity,and the pathogenesis of daytime sleepiness may be related to LEP level changes.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 肥胖 嗜睡 瘦素 

分 类 号：R766[医药卫生—耳鼻咽喉科]