黄葵胶囊对糖尿病肾病血液透析患者微炎症和氧化应激状态的影响  

Effects of okra capsule on microinflammation and oxidative stress in hemodialysis patients with diabetic nephropathy

作　　者：王晓松[1] WANG Xiaosong(Department of Nephrology,Quanzhou First Hospital,Fujian,Quanzhou 362000,China)

机构地区：[1]福建省泉州市第一医院肾内科,福建泉州362000

出　　处：《中国医药科学》2020年第8期56-59,共4页China Medicine And Pharmacy

摘　　要：目的探究黄葵胶囊对糖尿病肾病血液透析患者微炎症和氧化应激状态的影响。方法选取我院2018年1月~2019年6月收治的行血液透析治疗的糖尿病肾病患者90例,根据随机数字表法分为观察组45例和对照组45例。观察组采用黄葵胶囊辅助治疗,对照组则给予常规性辅助治疗,比较两组的微炎症指标和氧化应激情况。结果治疗前两组患者hs-CRP、IL-6和TNF-α等微炎症指标水平差异无统计学意义(P>0.05);治疗后,两组hs-CRP、IL-6和TNF-α水平均低于治疗前,同时观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组MDA、SOD和GSH-Px等氧化应激指标水平差异无统计学意义(P>0.05);治疗后,两组MDA、SOD和GSH-Px水平均较治疗前有变化,其中观察组MDA水平低于对照组,SOD和GSH-Px水平高于对照组,差异有统计学意义(P<0.05)。结论糖尿病肾病血液透析治疗时,辅助黄葵胶囊治疗,可以改善患者的微炎症和氧化应激状态,值得推广。Objective To investigate the effects of okra capsule on microinflammation and oxidative stress in hemodialysis patients with diabetic nephropathy.Methods 90 diabetic nephropathy patients receiving hemodialysis admitted and treated at our hospital from January 2018 to June 2019 were selected,and divided into the observation group and the control group according to the digital random table method,with 45 patients in each group.The observation group received okra capsule adjuvant therapy,while the control group was given routine adjuvant therapy.Microinflammatory indexes and oxidative stress were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of microinflammatory indexes such as hs-CRP,IL-6,TNF-α,etc.between the two groups(P>0.05);After treatment,the levels of hs-CRP,IL-6 and TNF-αin the two groups were lower than those before treatment,while those in the observation group were lower than those in the control group,with statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in the levels of oxidative stress indexes such as MDA,SOD,GSH-Px,etc.between the two groups(P>0.05);After treatment,the levels of MDA,SOD and GSH-Px in the two groups were changed compared with those before treatment,wherein the level of MDA in the observation group was lower than that in the control group,while the levels of SOD and GSH-Px were higher than those in the control group,with statistically significant difference(P<0.05).Conclusion In the hemodialysis therapy of diabetic nephropathy,the okra capsule adjuvant therapy can improve the microinflammation and oxidative stress of patients,which is worthy of promotion.

关 键 词：黄葵胶囊 糖尿病肾病 血液透析 微炎症 氧化应激 

分 类 号：R587.2[医药卫生—内分泌]