基于数据挖掘分析王仲奇治疗时邪用药规律  

Analysis on WANG Zhongqi’s Medication Regularity in Treating Seasonal Pathogen Based on Data Mining

作　　者：李家劼 王键[1] 黄辉[1] 郭锦晨 纵艳平 周桥 LI Jiajie;WANG Jian;HUANG Hui;GUO Jinchen;ZONG Yanping;ZHOU Qiao(College of Chinese Medicine,Anhui University of Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽中医药大学中医学院,安徽合肥230038

出　　处：《山东中医药大学学报》2020年第3期229-234,共6页Journal of Shandong University of Traditional Chinese Medicine

基　　金：“十二五”国家科技支撑计划“新安医学传承与发展研究”(编号:2012BAI26B00);国家中医药管理局“新安王氏内科流派传承工作室”建设项目(编号:[国中医药人教函(2012)228号]);安徽中医药大学大学生创新创业项目(编号:2018110);2019年度安徽省人文社科重点研究基地招标项目(编号:SK2019A0248)。

摘　　要：目的:探讨新安医家王仲奇治疗时邪病的处方用药特色。方法:从《王仲奇医案》中选取王仲奇治疗时邪病的有效处方74首,利用Office 2010处理数据,进行数据挖掘,应用数据分析软件IBM SPSS Modeler 14.1和SPSS 22.0,分别对所用药物的用药频数、性味归经、药物类别、聚类规则及关联规则等进行分析。结果:用药频数前五位分别是茯苓、苦杏仁、佩兰、通草、半夏。药类及性味归经频数分析显示清热药、化痰药、补虚药和解表药位居前四位;以苦寒之药佐甘温之药,寒温并用;药物以入脾胃经为主,兼顾肺气的功能,脾肺同调。聚类规则分析显示处方含金银花、天花粉、石斛等9类药物。关联分析得出二项配伍药对前3位为苦杏仁、前胡,茯苓、黄芩,苦杏仁、黄芩;三项配伍前3位为苦杏仁、枳壳、茯苓,茯苓、青蒿、苦杏仁,茯苓、薏苡仁、佩兰。结论:王仲奇辨证论治时邪病时,以三焦为本,多从湿热入手,治疗以苦寒药与甘温药并用,驱温热,化湿浊,时邪亦解矣。Objective:To explore Xin’an physician WANG Zhongqi’s medication characteristics in the treatment of seasonal pathogenic diseases.Methods:A total of 74 effective prescriptions in treating seasonal pathogenic diseases were selected from The Medical Case of WANG Zhongqi.Data was processed and mined by Office 2010.The drug application data analysis software IBM SPSS Modeler 14.1 and SPSS 22.0 were used to analyze medication frequency,property,flavor,channel tropism,category,clustering rules and association rules,etc.Results:The top five most frequently used herbs were Fuling(Poria),Kuxingren(Armeniacae Semen Amarum),Peilan(Eupatorii Her-ba),Tongcao(Tetrapanacis Medulla)and Banxia(Pin-elliae Rhizoma).According to the frequency analy-sis of category,property,flavor and channel tropism,herbs for clearing-heat,resolving-phlegm,tofinying-de-ficiency and relieving-exterior ranked the top four.Bitter-cold medicinals assisted sweet-warm medicinals,combining cold and warm medicinals.The medicinals mainly entered spleen and stomach meridians,taking into account the function of lung qi and regulating spleen and lung at the same time.The results of clustering rule analysis were Jinyinhua(Lonicerae Japonicae Flos),Tianhuafen(Trichosanthis Radix)and Shihu(Dendrobii Caulis),etc,total 9 medicinals.The results of correlation analysis showed that the top 3 combinations of two medicinals were Kuxingren and Qianhu(Peucedani Radix),Fuling and Huangqin(Scutellariae Radix),Kuxingren and Huangqin.The top 3 combinations of three medicinals were Kuxingren,Zhiqiao(Aurantii Fructus)and Fuling,Fuling,Qinghao(Artemisiae Annuae Herba)and Kuxingren,Fuling,Yiyiren(Coicis Semen)and Peilan.Conclusions:In the treatment of seasonal pathogenic diseases based on syndrome differentiation,WANG Zhongqi applied both bitter-cold medicinals and sweet-warm medicinals,dispelling warm-heat and resolving turbid dampness with good effects.

关 键 词：王仲奇 时邪 数据挖掘 用药规律 性味归经 药物类别 聚类规则 关联规则 新安医学 

分 类 号：R289.5[医药卫生—方剂学]