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作 者:彭静 张文[1] 栾家杰[1] PENG Jing;ZHANG Wen;LUAN Jia-jie(Department of Pharmacy,Yijishan Hospital,Wannan Medical College,Wuhu,Anhui 241000,China)
机构地区:[1]皖南医学院弋矶山医院药学部,安徽芜湖241000
出 处:《解放军医药杂志》2020年第5期53-56,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基 金:安徽省自然科学基金项目(H3111);安徽省自然科学基金项目(1608085MH178)。
摘 要:目的探讨阿卡波糖联合格列吡嗪治疗2型糖尿病的临床疗效及安全性。方法选取2016年12月-2018年12月本院收治的400例2型糖尿病患者的临床资料进行回顾性分析,按治疗方法分为对照组和观察组,每组200例。对照组给予格列吡嗪口服,观察组在此基础上加用阿卡波糖,2组均连续治疗3个月。比较2组治疗前后血糖指标、胰岛B细胞功能指标、血脂指标、凝血指标水平;比较2组临床疗效及不良反应发生情况。结果与治疗前相比,2组治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白及甘油三酯、胆固醇水平均降低,且观察组低于对照组(P<0.05,P<0.01)。2组治疗后胰岛B细胞功能指数、空腹胰岛素、餐后2 h胰岛素、凝血酶原和部分凝血酶原时间均高于治疗前,且观察组上述指标高于对照组(P<0.01)。2组治疗后胰岛素抵抗指数、纤维蛋白原含量均低于治疗前,且观察低于对照组(P<0.01)。观察组总有效率高于对照组(P<0.01)。2组总不良反应发生率比较差异无统计学意义(P>0.05)。结论阿卡波糖联合格列吡嗪可调节2型糖尿病患者的糖脂代谢,可恢复其胰岛功能及凝血功能,安全性良好。Objective To explore the clinical effect and safety of Acarbose combined with Glipizide in the treatment of type 2 diabetes mellitus(T2 DM). Methods The clinical data of 400 cases patients with T2 DM admitted to our hospital from December 2016 to December 2018 were selected and retrospectively analyzed. According to different treatment methods, the patients were divided into control group and observation group, with 200 cases in each group. The control group was given Glipizide orally, and the observation group was supplemented with Acarbose. Both groups were treated continuously for 3 months. The levels of blood glucose, islet β-cell function, blood lipid and coagulation were compared between the two groups after treatment. The clinical efficacy and adverse reactions of the two groups were compared. Results Compared with the control group, the fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin, triglyceride and cholesterol levels in the two groups were decreased after treatment, which was lower in the observation group than in the control group(P<0.05, P<0.01). The B-cell function index, fasting insulin, 2-hour postprandial insulin, prothrombin and partial prothrombin time in the two groups were all higher than those before treatment, and those in the observation group were higher than those in the control group(P<0.01). After treatment, the insulin resistance index and fibrinogen content of the two groups were lower than those before treatment, which was lower in the observation group than in the control group(P<0.01). The total effective rate of the observation group was higher than that of the control group(P<0.01). There was no significant difference in the incidence of total adverse reactions between the two groups(P>0.05). Conclusion Acarbose combined with Glipizide can effectively regulate the metabolism of glucose and lipids of patients with T2 DM, and restore islet function and blood coagulation function, which has good safety.
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