儿童脓毒症患儿血清可溶性髓样细胞触发受体-1、可溶性CD14亚型、前降钙素和超敏C反应蛋白水平的变化  

Changes of soluble triggering receptor expressed on myeloid cells-1,soluble CD14 subtype,procalcitonin and hypersensitive C-reactive protein in the serum of children with sepsis

作　　者：蓝俊伟[1] 潜丽俊[1] LAN Junwei;QIAN Lijun(Department of Pediatrics,Lishui City Central Hospital in Zhejinag Province,Lishui 323000,China)

机构地区：[1]浙江省丽水市中心医院儿科,浙江丽水323000

出　　处：《中国现代医生》2020年第8期23-26,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2016KYB337)。

摘　　要：目的探讨儿童脓毒症患儿血清可溶性髓样细胞触发受体-1(sTREM-1)、可溶性CD14亚型(sCD14-ST)、前降钙素(PCT)和超敏C反应蛋白(hs-CRP)水平的变化。方法选取2015年1月~2018年8月儿科住院治疗儿童脓毒症患儿50例作为观察组,根据其病情程度分为严重脓毒症18例与非严重脓毒症32例。另选择同期在我院体检中心检查的正常健康儿童30例为对照组。比较对照组与观察组、严重脓毒症及非严重脓毒症血清sTREM-1、sCD14-ST、PCT和hs-CRP水平。结果观察组患儿血清sTREM-1、sCD14-ST、PCT和hs-CRP水平明显高于对照组,差异有统计学意义(P<0.01);严重脓毒症患儿sTREM-1、sCD14-ST、PCT和hs-CRP水平明显高于非严重脓毒症患儿,差异有统计学意义(P<0.05或P<0.01)。结论血清sTREM-1、sCD14-ST、PCT和hs-CRP水平不仅可用于儿童脓毒症早期诊断,而且可评估患儿病情严重程度。Objective To investigate the changes of soluble triggering receptor expressed on myeloid cells-1(STREM-1),soluble CD14 subtype(sCD14-ST),procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)in the serum of children with sepsis.Methods A total of 50 children with sepsis who were hospitalized in the department of pediatrics from January 2015 to August 2018 were enrolled as the observation group.According to the severity of the disease,there were 18 cases of severe sepsis and 32 cases of non-severe sepsis.Another 30 healthy children who were examined at the physical examination center of our hospital during the same period were selected as the control group.Serum sTREM-1,sCD14-ST,PCT and hs-CRP levels were compared between control and observation groups,severe sepsis and non-severe sepsis patients.Results Serum levels of sTREM-1,sCD14-ST,PCT and hs-CRP in the observation group were significantly higher than those in the control group(P<0.01).The levels of sTREM-1,sCD14-ST,PCT and hs-CRP in children with severe sepsis were significantly higher than those of non-severe sepsis patients,and the difference was statistically significant(P<0.05 or P<0.01).Conclusion Serum sTREM-1,sCD14-ST,PCT and hs-CRP levels can be used not only for early diagnosis of sepsis in children,but also for assessing the severity of the disease.

关 键 词：脓毒症 儿童 可溶性髓样细胞触发受体-1(sTREM-1) 可溶性CD14亚型(sCD14-ST) 前降钙素(PCT) 超敏C反应蛋白(hs-CRP) 

分 类 号：R459.7[医药卫生—急诊医学]