产后深静脉血栓形成患者血清CD40L含量与凝血及血小板、炎症反应程度的相关性研究  

Correlation between serum CD40L content and coagulation, platelet and inflammatory response in patients with postpartum deep venous thrombosis

作　　者：姜德颖[1] JIANG Deying(Department of Vascular Surgery,Dalian Central Hospital,Dalian116033,China)

机构地区：[1]大连市中心医院血管外科,辽宁大连116033

出　　处：《中国现代医生》2020年第9期52-55,共4页China Modern Doctor

摘　　要：目的研究产后深静脉血栓(DVT)患者血清CD40配体(CD40L)含量与凝血及血小板功能、炎症反应程度的相关性。方法选取2017年6月~2019年8月我院分娩后发生深静脉血栓的产妇作为DVT组,另选取同期我院分娩后健康的产妇作为对照A组及正常体检女性(未妊娠)作为对照B组。测定外周血中CD40L及凝血指标、血小板功能参数及炎症细胞因子。结果 DVT组CD40L水平明显高于对照A组及对照B组,差异有统计学意义(P<0.05)。DVT组APTT、PT水平低于对照A组及对照B组,D-D、FIB水平明显高于对照A组及对照B组;对照A组APTT、PT水平低于对照B组,D-D、FIB水平明显高于对照B组,差异均有统计学意义(P<0.05)。DVT组PAF、P-selectin、vWF水平明显高于对照A组及对照B组,对照A组PAF、P-selectin、vWF水平明显高于对照B组,差异均有统计学意义(P<0.05)。DVT组TNF-α、IL-10、CRP水平明显高于对照A组及对照B组,对照A组TNF-α、IL-10、CRP的水平明显高于对照B组,差异均有统计学意义(P<0.05)。CD40L与APTT、PT呈负相关,与D-D、FIB、PAF、P-selectin、vWF、TNF-α、IL-10、CRP呈正相关(P<0.05)。结论 CD40L的增多能促进分娩后产妇的凝血、血小板聚集及活化炎症反应,从而增加深静脉血栓的发生率。Objective To study the correlation between serum CD40 ligand(CD40 L) content and blood coagulation,platelet function, and inflammatory response in patients with postpartum deep venous thrombosis(DVT). Methods The women with DVT after delivery treated in our hospital from June 2017 to August 2019 were selected as the DVT group,and the healthy women after delivery admitted to our hospital during the same period were selected as the control group A and the women undergoing normal physical examination(not pregnant) were selected as the control group B. CD40 L and coagulation parameters, platelet function parameters and inflammatory cytokines were measured in peripheral blood. Results The CD40 L level in DVT group was significantly higher than that in control group A and control group B, and the difference was statistically significant(P<0.05);activated partial thromboplastin time(APTT) and prothrombin time(PT) levels in DVT group were lower than those in control group A and control B,and D-dimer(D-D) and fibrinogen(FIB) levels were significantly higher than those in control A and control group B;APTT and PT levels in control group A were lower than those in control group B, and D-D and FIB levels were significant higher than those in control group B, and the differences between the groups were statistically significant(P<0.05). The levels of Platelet-Activating Factor(PAF), P-selectin, and von Willebrand factor(vWF) in DVT group were significantly higher than those in the control group A and B, and the levels of PAF, P-selectin, and vWF in the control group A were significantly higher than those in the control group B, and the differences were statistically significant(P<0.05). The levels of tumor necrosis factor-α(TNF-α), interleukin-10(IL-10), and C-reactive protein(CRP) in DVT group were significantly higher than those in the control group A and B, and the levels of TNF-α, IL-10, and CRP in the control group A were significantly higher than those in the control group B, and the differences between the groups we

关 键 词：深静脉血栓 分娩 CD40配体 凝血功能 血小板活化 炎症反应 

分 类 号：R714.46[医药卫生—妇产科学]