丹参川芎嗪注射液联合二磷酸果糖治疗新生儿窒息后心肌损伤的效果及机制研究  

Research on effect and mechanism of salvia ligustrazine injection combined with fructose diphosphate in treatment of myocardial injury after neonatal asphyxia

作　　者：于波[1] YU Bo(Department of Neonatology,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院新生儿科,黑龙江佳木斯154002

出　　处：《中国现代医生》2020年第9期137-140,共4页China Modern Doctor

摘　　要：目的探讨丹参川芎嗪注射液联合二磷酸果糖治疗新生儿窒息后心肌损伤的临床效果以及机制。方法选取2017年1月~2019年3月我院收治的60例新生儿窒息后心肌损伤患儿,采用随机数字表法分为观察组及对照组,每组30例,对照组予二磷酸果糖治疗,观察组在对照组的基础上加用丹参川芎嗪注射液,比较两组患儿的临床治疗效果与不良反应,治疗前后的肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、N端脑利钠肽前体(NTproBNP)的变化及左室射血分数(LVEF)。结果观察组患儿的治疗有效率明显高于对照组(P<0.05),两组患儿均未发生严重不良反应。治疗前,两组患儿的CK、CK-MB、NT-proBNP、LVEF水平比较,差异无统计学意义(P>0.05);治疗后两组患儿的CK、CK-MB、NT-proBNP水平低于治疗前,LVEF水平高于治疗前(P<0.05),但观察组的CK、CK-MB、NT-proBNP、LVEF的改善程度明显优于对照组(P<0.05)。结论丹参川芎嗪注射液联合二磷酸果糖治疗新生儿窒息后心肌损伤效果显著,其机制与降低CK、CK-MB、NT-proBNP水平、提高LVEF水平有关。Objective To explore the clinical effect and mechanism of salvia ligustrazine injection combined with fructose diphosphate in the treatment of myocardial injury after neonatal asphyxia. Methods A total of 60 infants with myocardial injury after neonatal asphyxia who were admitted to our hospital from January 2017 to March 2019 were selected and divided into the observation group and the control group according to the random number table, with 30 infants in each group. The control group was treated with fructose diphosphate, and the observation group was added with salvia ligustrazine injection on the basis of the control group. Clinical therapeutic effects, adverse reactions, and changes in creatine kinase(CK), creatine kinase isoenzyme(CK-MB), N-terminal brain natriuretic peptide precursor(NT-proBNP), and left ventricular ejection fraction(LVEF) before and after treatment were compared between the two groups. Results The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). No serious adverse reactions were observed in the two groups. Before treatment, no differences were observed in the levels of CK, CK-MB, NT-proBNP and LVEF between the two groups(P>0.05). After treatment, the levels of CK, CK-MB and NT-proBNP in the two groups were lower than those before treatment, and the LVEF level was higher than that before treatment(P<0.05). However, the improvements of CK, CK-MB, NT-proBNP and LVEF in the observation group were significantly better than those in the control group(P<0.05). Conclusion Salvia ligustrazine injection combined with fructose diphosphate has a significant effect in the treatment of myocardial injury after neonatal asphyxia, and its mechanism is related to the ability of reducing the levels of CK, CK-MB and NT-proBNP and improving the level of LVEF.

关 键 词：丹参川芎嗪注射液 二磷酸果糖 新生儿窒息 心肌损伤 

分 类 号：R722.12[医药卫生—儿科]