呼吸道病毒感染与热性惊厥的关系研究  

Study on relationship between respiratory viral infection and febrile seizure

作　　者：杨艳娥[1] 孟远翠 YANG Yan′e;MENG Yuancui(Department of Pediatrics,Second Affiliated Hospital of Xi′an Medical Colledge,Xi′an,Shaanxi 710038,China)

机构地区：[1]西安医学院第二附属医院儿科,陕西西安710038

出　　处：《检验医学与临床》2020年第10期1370-1372,共3页Laboratory Medicine and Clinic

摘　　要：目的分析不同年龄段热性惊厥(FS)患儿中常见的呼吸道病毒感染类型,为FS的预防和治疗提供参考。方法选取134例FS患儿为FS组,并选择同期100例发热未发生惊厥的患儿为对照组,把两组患儿根据年龄再分为6个月至2岁组及>2~5岁组。采用直接免疫荧光法对其鼻咽部脱落细胞进行呼吸道常见病毒检测。结果在6个月至2岁的患儿中FS组单纯疱疹病毒6(31.65%)、流感病毒A(27.85%)的感染率明显高于对照组(22.41%、17.24%),差异有统计学意义(P<0.05);在>2~5岁患儿中FS组流感病毒A感染率(49.09%)明显高于对照组(10.64%),差异有统计学意义(P<0.05)。两组其他呼吸道病毒感染率比较差异无统计学意义(P>0.05)。结论2岁以下的FS患儿中单纯疱疹病毒6及流感病毒A感染多见,而>2岁的FS患儿中流感病毒A感染多见,如果在病毒流行季节早期进行干预,可能有利于防止FS的发生。Objective To analyze the types of respiratory tract viral infection in different age periods of children patients with febrile seizure(FS)to provide reference for the prevention and treatment of FS.Methods One hundred and thirty-four children patients with fever complicating FS were selected as the FS group.Contemporaneous 100 children patients with fever without seizure were selected as the control group.The two groups were re-divided into the 6 months old to 2 years old group and>2-5 years old group.The common viruses in exfoliated cells from nasopharyneal site were detected by adopting the direct immunofluorescence method.Results The infection rates of herpes simplex virus 6(31.65%)and influenza A(27.85%)in the 6 month old to 2 years old group were significantly higher than those in the control group(22.41%,17.24%),and the difference was statistically significant(P<0.05);in the>2-5 years old group,the infection rate of influenza A was significantly higher than that in the control group,and the difference was statistically significant(49.09%vs.10.64%,P<0.05).But the infection rates of other respiratory tract viruses had no statistical difference between the two groups(P>0.05).Conclusion The infection of herpes simplex virus 6 and influenza virus A are common in children patients aged under 2 years old with FS,while influenza virus A infection is common in children patients aged>2 years old.Conducting the intervention in the early stage of viral prevalence seasons can be conducive to prevent the FS occurrence.

关 键 词：发热性惊厥 流感病毒A型 单纯疱疹病毒属 

分 类 号：R725.9[医药卫生—儿科]