rhEGF联合皮肤软组织扩张器对面颈部瘢痕整形患者TLR4水平和Ⅰ/Ⅲ型胶原比值的影响  

The effect of rhEGF combined with skin and soft tissue expander on TLR4 level and typeⅠcollagenⅢratio in patients with facial and neck scar plastic surgery

作　　者：刘鸿雁[1] 蒋婷[1] 黄文炼 蒲晓姝 LIU Hong-yan;JIANG Ting;HUANG Wen-lian;PU Xiao-shu(Department of Burns Plastic Surgery, Nanchong Central Hospital, Second Affilited to North Sichuan Medical University, Nanchong 637099, China)

机构地区：[1]川北医学院第二临床医学院,南充市中心医院烧伤整形美容外科,四川南充637099

出　　处：《河北医科大学学报》2020年第5期566-569,共4页Journal of Hebei Medical University

基　　金：国家自然科学基金青年科学基金(81301568);四川省教育厅科研计划(17ZA0181)。

摘　　要：目的研究重组人表皮细胞生长因子(recombinant human epidermal cell length factor,rhEGF)联合皮肤软组织扩张器对面颈部瘢痕整形患者TLR4水平及Ⅰ/Ⅲ型胶原比值的影响。方法选择面颈部瘢痕整形患者108例,按随机数字表法分为观察组和对照组。对照组采用皮肤软组织扩张术治疗,观察组采用rhEGF和皮肤软组织扩张术治疗。比较2组即时回缩率、皮肤扩张率、扩张时间、Ⅰ/Ⅲ型胶原比值、羟脯氨酸(hydroxyprolin,OHP)含量、Toll样受体4(Toll-like receptor4,TLR4)表达水平、临床疗效、不良事件发生情况。结果观察组即时回缩率、扩张完成时间、Ⅰ/Ⅲ型胶原比值均显著低于对照组,观察组皮肤扩张率、OHP含量显著高于对照组(P<0.01)。观察组修复效果优于对照组,总有效率高于对照组(P<0.01)。第2期手术时,2组TLR4表达水平明显低于治疗前,观察组TLR4表达水平低于对照组(P<0.01)。观察组不良反应发生率明显低于对照组(P<0.01)。结论rhEGF联合皮肤软组织扩张器治疗面颈部瘢痕整形效果良好,不良反应发生率低,安全性好。Objective To study effects of the human recombinant epidermal cell growth factor,recombinant human epidermal cell length factor(rhEGF)combined with skin and soft tissue expander on TLR4 level and typeⅠcollagenⅢratio in patients with facial and neck scar plastic surgery.Methods A total of 108 patients with facial and neck scar were selected and divided into observation group and control group,according to the random number table method.The control group was treated with skin and soft tissue dilatation,while the observation group was treated with rhEGF and skin and soft tissue dilatation.Compare the immediate retraction rate,skin expansion ratio,expansion time,collagen typeⅠ/Ⅲratio,hydroxyproline(hydroxyprolin,OHP)content,Toll-like receptor 4(Toll-like receptor4,TLR4)expression level,clinical efficacy,adverse events of 2 groups of patients.Results In the observation group,immediate retraction rate,expansion of completion time,collagen typeⅠ/Ⅲratio were significantly lower than those of the control group,and skin expansion rate and OHP of the observation group were significantly higher than those of control group(P<0.01).The repair effect of the observation group was better than that of the control group,and the total effective rate was higher than that of the control group(P<0.01).Conclusion RhEGF combined with skin and soft tissue expander has a good effect in the treatment of facial and neck scar,with low incidence of adverse reactions and good safety.

关 键 词：瘢痕 外科 整形 表皮生长因子 组织扩张 

分 类 号：R619.6[医药卫生—外科学]