扶土生金康复方治疗COVID-19恢复期肺脾不足证患者临床观察  

Clinical Observation of the Rehabilitation Formula for Banking up Earth to Generate Metal in Treating COVID-19 Patients with Deficiency of Lung and Spleen Syndrome in the Recovery Stage

作　　者：史锁芳[1] 方祝元[1] 熊侃 叶德梁 汪为民[3] 陈永昶 吴迪 李昀泽[1] 张月清 崔磊[3] 陈明祺[1] 王博寒 SHI Suo-fang;FANG Zhu-yuan;XIONG Kan;YE De-liang;WANG Wei-min;CHEN Yong-chang;WU Di;LI Yun-ze;ZHANG Yue-qing;CUI Lei;CHEN Ming-qi;WANG Bo-han(Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China;Department of Lung Diseases of TCM, Jiangxia Hospital of Chinese Medicine, Wuhan, 430200, China;Department of Lung Diseases of TCM, Huai'an Hospital of Chinese Medicine, Huai'an, 223200, China;Department of Lung Diseases of TCM, Yangzhou Hospital of Chinese Medicine, Nanjing, 225009, China;Department of Infectious Diseases, Zhenjiang Third People's Hospital, Zhenjiang, 212003, China;Department of Neurology, Huai'an Hospital, Huai'an, 223200, China;The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China)

机构地区：[1]南京中医药大学附属医院/江苏省中医院,江苏南京210029 [2]武汉市江夏区中医院中医肺病科,湖北武汉430200 [3]淮安市中医院中医肺病科,江苏淮安223200 [4]扬州市中医院中医肺病科,江苏南京225009 [5]镇江市第三人民医院传染病科,江苏镇江212003 [6]淮安医院神经科,江苏淮安223200 [7]南京中医药大学第一临床医学院,江苏南京210023

出　　处：《南京中医药大学学报》2020年第3期281-285,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省重点研发计划(BE2020617);江苏省中医药科技专项计划(JSZYJ202002)。

摘　　要：目的观察扶土生金康复方治疗新型冠状病毒肺炎(COVID-19)恢复期肺脾不足证患者的中医证候疗效及对免疫学等相关指标的影响。方法将120例COVID-19恢复期肺脾不足证患者分为治疗组89例和对照组31例,治疗组给予扶土生金康复方治疗,对照组无任何干预措施,疗程为14 d。观察2组治疗前后中医证候积分变化情况,并比较2组总有效率。观察2组治疗前后体液免疫和T淋巴细胞亚群相关指标变化情况。结果治疗后治疗组中医证候积分总有效率为94.38%,高于对照组54.84%(P<0.01)。治疗组IgA、补体C3水平明显降低(P<0.01),IgG、IgM水平明显升高(P<0.05),与对照组比较,IgM、补体C3水平有显著性差异(P<0.05~0.01)。治疗组CD3、CD4、CD8百分比明显升高(P<0.01),与对照组比较,CD3、CD4百分比有显著性差异(P<0.05)。结论扶土生金康复方能够有效改善COVID-19恢复期肺脾不足证患者的中医临床症状,并且能较好地改善患者免疫功能。OBJECTIVE To discuss the influence of the rehabilitation formula for banking up earth to generate metal on COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage in terms of clinical efficacy and immunology-related indexes.METHODS 120 COVID-19 patients with deficiency of lung and spleen syndrome in the recovery stage were divided into the treatment group(89 cases)and the control group(31 cases).The rehabilitation formula for banking up earth to generate metal was given to the treatment group while the control group was not given any interventions.The course was 14 days.The symptom scores were observed before and after treatment in the two groups and the effective rates in the two groups were compared.RESULTS The effective rate of the treatment group was 94.38%,higher than 54.84%in the control group(P<0.01).The symptom scores before and after treatment in group A and B had no significant differences(P>0.05),and so did the effective rate(P>0.05).The levels of IgA,Complement C3 after the treatment group were lower than those before treatment(P<0.01).The percentages of CD3,CD4 and CD8 were higher after the treatment group than those before(P<0.01).Compared with those in the control group,the percentages of CD3 and CD4 in the treatment group had significant difference(P<0.05).CONCLUSION The rehabilitation formula for banking up earth to generate metal can effectively improve the clinical symptoms caused by deficiency of lung and spleen for COVID-19 patients in the recovery stage as well as their immunologic function.

关 键 词：COVID-19 恢复期 肺脾不足证 扶土生金康复方 疗效分析 

分 类 号：R247.9[医药卫生—中医临床基础]