姜黄素微乳凝胶治疗放疗后皮肤纤维化的临床研究  

Clinical Research of Curcumin Microemulsion Gel on Skin Fibrosis after Radiotherapy

作　　者：韩桂香 刘嘉 马朝群[2] 朱萱萱[2] 张迪[2] HAN Gui-xiang;LIU Jia;MA Chao-qun;ZHU Xuan-xuan;ZHANG Di(School of Chinese and Western Medicine of Jiangsu Health Vocational College, Nanjing, 211800, China;Affiliated Hospital of Nanjing University of Chinese Medicine /Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China)

机构地区：[1]江苏卫生健康职业学院中西医结合学院,江苏南京211800 [2]南京中医药大学附属医院/江苏省中医院,江苏南京210029

出　　处：《南京中医药大学学报》2020年第3期318-321,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省中医药局科技项目(YB2015174);江苏省高校“青蓝工程”(苏教师〔2017〕15号);浦口区科普部委托项目(PKKP2017-05)。

摘　　要：目的探讨姜黄素微乳凝胶治疗放疗后皮肤纤维化的疗效及其对纤维化指标因子的影响。方法选取2017年3月-2018年12月在南京中医药大学附属医院肿瘤科确诊的80例肿瘤放疗后皮肤纤维化患者,设姜黄素微乳凝胶为治疗组,积雪苷霜软膏为对照组,每天皮肤给药2次,连续2个月。考察对比2组患者的总有效率、西医评分、中医证候评分及纤维化因子的表达。结果治疗后治疗组总有效率为92.5%,优于对照组的77.5%(P<0.05);2组西医疗效评分明显改善(P<0.05),治疗组在改善关节痛方面显著优于对照组(P<0.05);2组中医证候评分改善(P<0.05),治疗组皮肤变硬、肢体麻木症状较对照组改善明显(P<0.05);2组血清纤维化因子羟脯氨酸(HYP)、转化生长因子-β(TGF-β)、结缔组织生长因子(CTGF)水平均显著下降(P<0.01),治疗组血清TGF-β和CTGF含量较对照组下降明显(P<0.05)。结论姜黄素微乳凝胶治疗放疗后皮肤纤维化疗效显著,能明显降低患者血液中的纤维化因子水平。OBJECTIVE To explore the curative effect of curcumin microemulsion gel on skin fibrosis after radiotherapy and the effect for fibrosis index factors.METHODS 80 patients with skin fibrosis diagnosed after tumor radiotherapy from March 2017 to December 2018 in the Department of Oncology of Affiliated Hospital of Nanjing university of Chinese medicine were selected.Curcumin microemulsion gel was set as the treatment group and asiaticoside cream was set as the control group,with 2 times daily skin administration for 2 consecutive months.The total effective rate,western medicine score,traditional Chinese medicine(TCM)syndrome score and expression of fibrosis factor in the two groups were compared.RESULTS After treatment,the total effective rate of the treatment group was 92.5%,better than 77.5%in the control group(P<0.05).Two groups of western medicine treatment efficacy scores were significantly improved(P<0.05).The treatment group was significantly better than the control group in improving the arthralgia(P<0.05).2 groups of TCM syndrome evaluations were improved(P<0.05).The skin of the treatment group was hard and the symptoms of limb numbness were better than those of the control group(P<0.05).The serum fibrinization factor hydroxyproline(HYP),transforming growth factor-β(TGF-β)and connective tissue growth factor(CTGF)of the two groups all decreased significantly(P<0.01).The contents of TGF-βand CTGF in blood serum of treatment group were significantly lower than those of control group(P<0.05).CONCLUSION Curcumin microemulsion gel treatment has significant effects on skin fibrosis after radiotherapy,and reduces the levels of fibrosis factor in patients'blood significantly.

关 键 词：姜黄素 微乳凝胶 放疗 皮肤纤维化 纤维化因子 

分 类 号：R269[医药卫生—中西医结合]